University of Surrey

Test tubes in the lab Research in the ATI Dance Research

Diterpenoids from the Roots of Croton dichogamus Pax

Aldhaher, A, Langat, Moses, Ndunda, B, Chirchir, D, Midiwo, JO, Njue, A, Schwikkard, S, Carew, M and Mulholland, Dulcie (2017) Diterpenoids from the Roots of Croton dichogamus Pax Phytochemistry, 144. pp. 1-8.

[img] Text
Croton_dichogamus final.docx - Accepted version Manuscript
Restricted to Repository staff only until 1 September 2018.

Download (207kB)
[img] Text
Croton graphic Mulholland_.pdf - Accepted version Manuscript
Restricted to Repository staff only until 1 September 2018.

Download (101kB)
[img] Text
SUPPORTING INFORMATION Croton.pdf - Accepted version Manuscript
Restricted to Repository staff only until 1 September 2018.

Download (5MB)

Abstract

Four previously undescribed diterpenoids including two crotofolanes, crotodichogamoin A and B, and two halimanes, crothalimene A and B, a new sesquiterpenoid, and fifteen previously reported compounds, including the crotofolane, crotohaumanoxide, the casbane, depressin, a further seven furanohalimane diterpenoids, three patchoulane and two further cadinane sesquiterpenoids and aleuritolic acid were isolated from the root of Croton dichogamus. Crotodichogamoin B is an important biosynthetic intermediate of the crotofolane class and this is the first report of patchoulene sesquiterpenoids from the genus. Compounds were tested at one concentration, 1x10-5 M, in the NCI59 cell one-dose screen but did not show significant activity snd were also evaluated for their cytotoxicity against Caco-2 cell lines using the neutral red assay. 10-epi-Maninsigin D reduced Caco-2 cell viability at 10, 30 and 100 µM, with values of decreased viability of 28%, 48% and 43% respectively. None of the other tested compounds showed significant activity.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences > Chemistry
Authors :
NameEmailORCID
Aldhaher, AUNSPECIFIEDUNSPECIFIED
Langat, MosesM.Langat@surrey.ac.ukUNSPECIFIED
Ndunda, BUNSPECIFIEDUNSPECIFIED
Chirchir, DUNSPECIFIEDUNSPECIFIED
Midiwo, JOUNSPECIFIEDUNSPECIFIED
Njue, AUNSPECIFIEDUNSPECIFIED
Schwikkard, SUNSPECIFIEDUNSPECIFIED
Carew, MUNSPECIFIEDUNSPECIFIED
Mulholland, DulcieD.Mulholland@surrey.ac.ukUNSPECIFIED
Date : 1 September 2017
Identification Number : 10.1016/j.phytochem.2017.08.014
Copyright Disclaimer : © 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Uncontrolled Keywords : Croton dichogamus, Euphorbiaceae, crotofolane, crotodichogamoin B, crothalimene A, crothalimene B, patchoulane, Caco-2 cell viability
Depositing User : Melanie Hughes
Date Deposited : 25 Aug 2017 10:42
Last Modified : 06 Oct 2017 15:19
URI: http://epubs.surrey.ac.uk/id/eprint/842041

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year


Information about this web site

© The University of Surrey, Guildford, Surrey, GU2 7XH, United Kingdom.
+44 (0)1483 300800