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Neutron diffraction study of antibacterial bioactive calcium silicate sol-gel glasses containing silver

Carta, Daniela, Jones, Julian R., Lin, Sen, Poologasundarampillai, Gowsihan, Newport, Robert J. and Pickup, David M. (2017) Neutron diffraction study of antibacterial bioactive calcium silicate sol-gel glasses containing silver International Journal of Applied Glass Science.

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Abstract

Bioactive sol-gel calcia-silica glasses can regenerate damaged or diseased bones due to their ability to stimulate bone growth. This capability is related to the formation of a hydroxyapatite layer on the glass surface, which bonds with bone, and the release of soluble silica and calcium ions in the body fluid which accelerates bone growth. The addition of silver ions imbues the glass with antibacterial properties due to the release of antibacterial Ag+ ion. The antibacterial activity is therefore closely dependent on the dissolution properties of the glasses which in turn are related to their atomic-level structure. Structural characterisation of the glasses at the atomic level is therefore essential in order to investigate and control the antibacterial properties of the glass. We have used neutron diffraction to investigate the structure of silver-containing calcia-silica sol-gel bioactive glasses with different Ag2O loading (0, 2, 4, 6 mol %). The presence of the silver had little effect on the host glass structure, although some silver metal nanoparticles were present. Results agreed with previous computer simulations.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences > Chemistry
Authors :
NameEmailORCID
Carta, Danielad.carta@surrey.ac.ukUNSPECIFIED
Jones, Julian R.UNSPECIFIEDUNSPECIFIED
Lin, SenUNSPECIFIEDUNSPECIFIED
Poologasundarampillai, GowsihanUNSPECIFIEDUNSPECIFIED
Newport, Robert J.UNSPECIFIEDUNSPECIFIED
Pickup, David M.UNSPECIFIEDUNSPECIFIED
Date : 2017
Copyright Disclaimer : This is the peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving
Depositing User : Clive Harris
Date Deposited : 25 Aug 2017 09:29
Last Modified : 25 Aug 2017 09:29
URI: http://epubs.surrey.ac.uk/id/eprint/842038

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