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Neutron diffraction study of antibacterial bioactive calcium silicate sol-gel glasses containing silver

Carta, Daniela, Jones, Julian R., Lin, Sen, Poologasundarampillai, Gowsihan, Newport, Robert J. and Pickup, David M. (2017) Neutron diffraction study of antibacterial bioactive calcium silicate sol-gel glasses containing silver International Journal of Applied Glass Science, 8 (4). pp. 364-371.

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Abstract

Bioactive sol-gel calcia-silica glasses can regenerate damaged or diseased bones due to their ability to stimulate bone growth. This capability is related to the formation of a hydroxyapatite layer on the glass surface, which bonds with bone, and the release of soluble silica and calcium ions in the body fluid which accelerates bone growth. The addition of silver ions imbues the glass with antibacterial properties due to the release of antibacterial Ag+ ion. The antibacterial activity is therefore closely dependent on the dissolution properties of the glasses which in turn are related to their atomic-level structure. Structural characterisation of the glasses at the atomic level is therefore essential in order to investigate and control the antibacterial properties of the glass. We have used neutron diffraction to investigate the structure of silver-containing calcia-silica sol-gel bioactive glasses with different Ag2O loading (0, 2, 4, 6 mol %). The presence of the silver had little effect on the host glass structure, although some silver metal nanoparticles were present. Results agreed with previous computer simulations.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences > Chemistry
Authors :
NameEmailORCID
Carta, Danielad.carta@surrey.ac.ukUNSPECIFIED
Jones, Julian R.UNSPECIFIEDUNSPECIFIED
Lin, SenUNSPECIFIEDUNSPECIFIED
Poologasundarampillai, GowsihanUNSPECIFIEDUNSPECIFIED
Newport, Robert J.UNSPECIFIEDUNSPECIFIED
Pickup, David M.UNSPECIFIEDUNSPECIFIED
Date : 12 September 2017
Identification Number : 10.1111/ijag.12318
Copyright Disclaimer : © 2017 The Authors. International Journal of Applied Glass Science published by American Ceramics Society (ACERS) and Wiley Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Depositing User : Clive Harris
Date Deposited : 25 Aug 2017 09:29
Last Modified : 20 Oct 2017 08:01
URI: http://epubs.surrey.ac.uk/id/eprint/842038

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