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Measurement of DNA repair activity in hepatocytes exposed to fatty acids

Healing, Eleanor, Meira, Lisiane, Aston, P.J., Tindall, M.J. and Elliott, Ruan (2016) Measurement of DNA repair activity in hepatocytes exposed to fatty acids In: Nutrition Society Summer Meeting, 11–14 July 2016, New technology in nutrition research and practice, 11-14 Jul 2016, Dublin, Ireland.

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Abstract

DNA repair capacity varies greatly between individuals, and evidence has begun to link this variation to cancer risk, obesity and related chronic diseases. There is also emerging evidence that dietary components can affect DNA repair, but research to date has been restricted by methods for measuring DNA repair. This study made use of newly developed microplate-based assays for the direct determination of DNA repair enzyme activities. Lipid loading of the HepG2 human hepatocellular carcinoma cell line was employed as a model to test the hypothesis that hepatic steatosis affects DNA repair activity via induction of oxidative stress.

Item Type: Conference or Workshop Item (Conference Paper)
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
NameEmailORCID
Healing, Eleanore.healing@surrey.ac.ukUNSPECIFIED
Meira, LisianeL.Meira@surrey.ac.ukUNSPECIFIED
Aston, P.J.UNSPECIFIEDUNSPECIFIED
Tindall, M.J.UNSPECIFIEDUNSPECIFIED
Elliott, RuanR.M.Elliott@surrey.ac.ukUNSPECIFIED
Date : 2016
Identification Number : 10.1017/S0029665116000872
Copyright Disclaimer : © The Authors 2016
Additional Information : 2016, E72
Depositing User : Clive Harris
Date Deposited : 23 Aug 2017 13:42
Last Modified : 23 Aug 2017 13:42
URI: http://epubs.surrey.ac.uk/id/eprint/842014

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