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Transcriptomic Analysis of PBMCs from Allergic Patients after Probiotic Treatment

Bourdeau, T, Spertini, F, Raymond, F, Audran, R, Gosoniu, L, Mercenier, A, Nutten, S, Blanchard, C and Elliott, Ruan (2017) Transcriptomic Analysis of PBMCs from Allergic Patients after Probiotic Treatment Austin Journal of Nutrition and Metabolism, 4 (1), id1046.

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Abstract

Background: Allergic rhinitis is one of the most prevalent manifestation of allergy, affecting over 15% of the population worldwide. Recent published clinical studies have shown that specific probiotics can improveallergic rhinitis clinical symptoms. Findings: In this study, thirty one adult volunteers suffering from allergic rhinitis were enrolled in a crossover study evaluating the efficacy of the consumption of a product containing either L. paracasei-fermented milk or the placebo. Transcriptomic analysis was performed on unstimulated PBMC after each treatment period and analysis was adjusted for the crossover design. No differences were observed between PBMCs from probiotic treated allergen challenged allergic patients and PBMCs from placebo treated allergen challenged allergic patients. Conclusion: This study shows that, in the blood compartment, PBMCs mRNA levels are too stable to mirror the changes of symptoms and alteration of cytokine expressions observed after a treatment with L. paracasei.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
NameEmailORCID
Bourdeau, TUNSPECIFIEDUNSPECIFIED
Spertini, FUNSPECIFIEDUNSPECIFIED
Raymond, FUNSPECIFIEDUNSPECIFIED
Audran, RUNSPECIFIEDUNSPECIFIED
Gosoniu, LUNSPECIFIEDUNSPECIFIED
Mercenier, AUNSPECIFIEDUNSPECIFIED
Nutten, SUNSPECIFIEDUNSPECIFIED
Blanchard, CUNSPECIFIEDUNSPECIFIED
Elliott, RuanR.M.Elliott@surrey.ac.ukUNSPECIFIED
Date : 25 April 2017
Copyright Disclaimer : © 2017 Bourdeau et al. All rights are reserved. This is an open access article under the CC BY 4.0 license
Uncontrolled Keywords : Allergic rhinitis; Probiotic; Grass pollen; PBMC; Transcriptomic
Depositing User : Clive Harris
Date Deposited : 23 Aug 2017 13:27
Last Modified : 23 Aug 2017 13:27
URI: http://epubs.surrey.ac.uk/id/eprint/842012

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