University of Surrey

Test tubes in the lab Research in the ATI Dance Research

Daily supplementation with 15 mg vitamin D2 compared with vitamin D3 to increase wintertime 25-hydroxyvitamin D status in healthy South Asian and white European women: a 12-wk randomized, placebo-controlled food-fortification trial

Tripkovic, Laura, Wilson, LR, Hart, Kathryn, Johnsen, Sigurd, de Lusignan, Simon, Smith, CP, Bucca, G, Penson, S, Chope, G, Elliott, Ruan , Hypponen, E, Berry, J L and Lanham-New, Susan (2017) Daily supplementation with 15 mg vitamin D2 compared with vitamin D3 to increase wintertime 25-hydroxyvitamin D status in healthy South Asian and white European women: a 12-wk randomized, placebo-controlled food-fortification trial American Journal of Clinical Nutrition, 106 (2). pp. 481-490.

[img] Text
Daily supplementation with 15µg of vitamin D2.docx - Accepted version Manuscript
Restricted to Repository staff only until 6 July 2018.

Download (597kB)

Abstract

Background: There are conflicting views in the literature as to whether vitamin D2 and vitamin D3 are equally effective in increasing and maintaining serum concentrations of 25-hydroxyvitamin D [25(OH)D], particularly at lower doses of vitamin D. Objective: We aimed to investigate whether vitamin D2 or vitamin D3 fortified in juice or food, at a relatively low dose of 15 μg/d, was effective in increasing serum total 25(OH)D and to compare their respective efficacy in South Asian and white European women over the winter months within the setting of a large randomized controlled trial. Design: A randomized, double-blind, placebo-controlled food-fortification trial was conducted in healthy South Asian and white European women aged 20–64 y (n = 335; Surrey, United Kingdom) who consumed placebo, juice supplemented with 15 μg vitamin D2, biscuit supplemented with 15 μg vitamin D2, juice supplemented with 15 μg vitamin D3, or biscuit supplemented with 15 μg vitamin D3 daily for 12 wk. Serum 25(OH)D was measured by liquid chromatography–tandem mass spectrometry at baseline and at weeks 6 and 12 of the study. Results: Postintervention in the 2 ethnic groups combined, both the vitamin D3 biscuit and the vitamin D3 juice groups showed a significantly greater absolute incremental change (Δ) in total 25(OH)D when compared with the vitamin D2 biscuit group [Δ (95% CI): 15.3 nmol/L (7.4, 23.3 nmol/L) (P < 0.0003) and 16.0 nmol/L (8.0, 23.9 nmol/L) ( P < 0.0001)], the vitamin D2 juice group [Δ (95% CI): 16.3 nmol/L (8.4, 24.2 nmol/L) (P < 0.0001) and 16.9 nmol/L (9.0, 24.8 nmol/L) (P < 0.0001)], and the placebo group [Δ (95% CI): 42.3 nmol/L (34.4, 50.2 nmol/L) (P < 0.0001) and 42.9 nmol/L (35.0, 50.8 nmol/L) (P < 0.0002)]. Conclusions: With the use of a daily dose of vitamin D relevant to public health recommendations (15 μg) and in vehicles relevant to food-fortification strategies, vitamin D3 was more effective than vitamin D2 in increasing serum 25(OH)D in the wintertime. Vitamin D3 may therefore be a preferential form to optimize vitamin D status within the general population. This trial was registered at www.controlled-trials.com as ISRCTN23421591.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
NameEmailORCID
Tripkovic, LauraLaura.Tripkovic@surrey.ac.ukUNSPECIFIED
Wilson, LRUNSPECIFIEDUNSPECIFIED
Hart, KathrynK.Hart@surrey.ac.ukUNSPECIFIED
Johnsen, SigurdS.Johnsen@surrey.ac.ukUNSPECIFIED
de Lusignan, SimonS.Lusignan@surrey.ac.ukUNSPECIFIED
Smith, CPUNSPECIFIEDUNSPECIFIED
Bucca, GUNSPECIFIEDUNSPECIFIED
Penson, SUNSPECIFIEDUNSPECIFIED
Chope, GUNSPECIFIEDUNSPECIFIED
Elliott, RuanR.M.Elliott@surrey.ac.ukUNSPECIFIED
Hypponen, EUNSPECIFIEDUNSPECIFIED
Berry, J LUNSPECIFIEDUNSPECIFIED
Lanham-New, SusanS.Lanham-New@surrey.ac.ukUNSPECIFIED
Date : 5 July 2017
Identification Number : 10.3945/​ajcn.116.138693
Copyright Disclaimer : © 2017 American Society for Nutrition
Uncontrolled Keywords : vitamin D; vitamin D2; vitamin D3; 25-hydroxyvitamin D; randomized controlled trial; food fortification; healthy women; South Asian; white European
Depositing User : Jane Hindle
Date Deposited : 15 Aug 2017 13:55
Last Modified : 22 Sep 2017 11:14
URI: http://epubs.surrey.ac.uk/id/eprint/841922

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year


Information about this web site

© The University of Surrey, Guildford, Surrey, GU2 7XH, United Kingdom.
+44 (0)1483 300800