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In vitro and in vivo modeling of lipid bioaccessibility and digestion from almond muffins: The importance of the cell-wall barrier mechanism

Grassby, Terri, Mandalari, G, Grundy, MM-L, Edwards, CH, Bisignano, C, Trombetta, D, Smeriglio, A, Chessa, S, Ray, S, Sanderson, J , Berry, SB, Ellis, PR and Waldron, KW (2017) In vitro and in vivo modeling of lipid bioaccessibility and digestion from almond muffins: The importance of the cell-wall barrier mechanism Journal of Functional Foods, 37. pp. 263-271.

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Abstract

food matrix (muffins) investigating whether the cell-wall barrier regulates the bioaccessibility of nutrients within this matrix. Muffins containing small (AF) or large (AP) particles of almond were digested in triplicate using an in vitro dynamic gastric model (DGM, 1 h) followed by a static duodenal digestion (8 h). AF muffins had 97.1 ± 1.7% of their lipid digested, whereas AP muffins had 57.6 ± 1.1% digested. In vivo digestion of these muffins by an ileostomy volunteer (0–10 h) gave similar results with 96.5% and 56.5% lipid digested, respectively. The AF muffins produced a higher postprandial triacylglycerol iAUC response (by 61%) than the AP muffins. Microstructural analysis showed that some lipid remained encapsulated within the plant tissue throughout digestion. The cell-wall barrier mechanism is the main factor in regulating lipid bioaccessibility from almond particles.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
NameEmailORCID
Grassby, Territ.grassby@surrey.ac.ukUNSPECIFIED
Mandalari, GUNSPECIFIEDUNSPECIFIED
Grundy, MM-LUNSPECIFIEDUNSPECIFIED
Edwards, CHUNSPECIFIEDUNSPECIFIED
Bisignano, CUNSPECIFIEDUNSPECIFIED
Trombetta, DUNSPECIFIEDUNSPECIFIED
Smeriglio, AUNSPECIFIEDUNSPECIFIED
Chessa, SUNSPECIFIEDUNSPECIFIED
Ray, SUNSPECIFIEDUNSPECIFIED
Sanderson, JUNSPECIFIEDUNSPECIFIED
Berry, SBUNSPECIFIEDUNSPECIFIED
Ellis, PRUNSPECIFIEDUNSPECIFIED
Waldron, KWUNSPECIFIEDUNSPECIFIED
Date : 4 August 2017
Funders : BBSRC
Identification Number : 10.1016/j.jff.2017.07.046
Copyright Disclaimer : Copyright 2017 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Depositing User : Melanie Hughes
Date Deposited : 15 Aug 2017 11:30
Last Modified : 15 Aug 2017 11:30
URI: http://epubs.surrey.ac.uk/id/eprint/841918

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