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Diurnal preference, mood and the response to morning light in relation to polymorphisms in the human clock gene PER3

Turco, M, Biscontin, A, Corrias, M, Caccin, L, Bano, M, Chiaromanni, F, Salamanca, M, Mattei, D, Salvoro, C, Mazzotta, G , De Pittà, C, Middleton, Benita, Skene, Debra, Montagnese, S and Costa, R (2017) Diurnal preference, mood and the response to morning light in relation to polymorphisms in the human clock gene PER3 Scientific Reports, 7 (6967). pp. 1-10.

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Abstract

PER3 gene polymorphisms have been associated with differences in human sleep-wake phenotypes, and sensitivity to light. The aims of this study were to assess: i) the frequency of allelic variants at two PER3 polymorphic sites (rs57875989 length polymorphism: PER34, PER35; rs228697 SNP: PER3C, PER3G) in relation to sleep-wake timing; ii) the effect of morning light on behavioural/circadian variables in PER34/PER34 and PER35/PER35 homozygotes. 786 Caucasian subjects living in Northern Italy donated buccal DNA and completed diurnal preference, sleep quality/timing and sleepiness/ mood questionnaires. 19 PER34/PER34 and 11 PER35/PER35 homozygotes underwent morning light administration, whilst monitoring sleep-wake patterns and the urinary 6-sulphatoxymelatonin (aMT6s) rhythm. No significant relationship was observed between the length polymorphism and diurnal preference. By contrast, a significant association was observed between the PER3G variant and morningness (OR = 2.10), and between the PER3G-PER34 haplotype and morningness (OR = 2.19), for which a mechanistic hypothesis is suggested. No significant differences were observed in sleep timing/ aMT6s rhythms between PER35/PER35 and PER34/PER34 subjects at baseline. After light administration, PER34/PER34 subjects advanced their aMT6s acrophase (p < 0.05), and showed a trend of advanced sleep-wake timing. In conclusion, significant associations were observed between PER3 polymorphic variants/their combinations and both diurnal preference and the response to light.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
NameEmailORCID
Turco, MUNSPECIFIEDUNSPECIFIED
Biscontin, AUNSPECIFIEDUNSPECIFIED
Corrias, MUNSPECIFIEDUNSPECIFIED
Caccin, LUNSPECIFIEDUNSPECIFIED
Bano, MUNSPECIFIEDUNSPECIFIED
Chiaromanni, FUNSPECIFIEDUNSPECIFIED
Salamanca, MUNSPECIFIEDUNSPECIFIED
Mattei, DUNSPECIFIEDUNSPECIFIED
Salvoro, CUNSPECIFIEDUNSPECIFIED
Mazzotta, GUNSPECIFIEDUNSPECIFIED
De Pittà, CUNSPECIFIEDUNSPECIFIED
Middleton, BenitaB.Middleton@surrey.ac.ukUNSPECIFIED
Skene, DebraD.Skene@surrey.ac.ukUNSPECIFIED
Montagnese, SUNSPECIFIEDUNSPECIFIED
Costa, RUNSPECIFIEDUNSPECIFIED
Date : 31 July 2017
Identification Number : 10.1038/s41598-017-06769-w
Copyright Disclaimer : © The Author(s) 2017. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Depositing User : Melanie Hughes
Date Deposited : 09 Aug 2017 11:19
Last Modified : 09 Aug 2017 11:19
URI: http://epubs.surrey.ac.uk/id/eprint/841867

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