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Changes in hematological indices and lymphocyte subsets in response to whole blood donation in healthy male donors

Borai, Anwar, Livingstone, Callum, Alsobhi, Enaam, Al sofyani, Abeer, Balgoon, Dalal, Farzal, Anwar, Almohammadi, Mohammed, Al-Amri, Abdulafattah, Bahijri, Suhad, Alrowaili, Daad , Bassiuni, Wafaa, Saleh, Ayman, Alrowaili, Norah and Abdelaal, Mohamed (2017) Changes in hematological indices and lymphocyte subsets in response to whole blood donation in healthy male donors Scandinavian Journal of Clinical and Laboratory Investigation, 77 (2). pp. 143-148.

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Abstract

Whole blood donation has immunomodulatory effects, and most of these have been observed at short intervals following blood donation. This study aimed to investigate the impact of whole blood donation on lymphocyte subsets over a typical inter-donation interval. Healthy male subjects were recruited to study changes in complete blood count (CBC) (n = 42) and lymphocyte subsets (n = 16) before and at four intervals up to 106 days following blood donation. Repeated measures ANOVA were used to compare quantitative variables between different visits. Following blood donation, changes in CBC and erythropoietin were as expected. The neutrophil count increased by 11.3% at 8 days (p < .001). Novel changes were observed in lymphocyte subsets as the CD4/CD8 ratio increased by 9.2% (p < .05) at 8 days and 13.7% (p < .05) at 22 days. CD16-56 cells decreased by 16.2% (p < .05) at 8 days. All the subsets had returned to baseline by 106 days. Regression analysis showed that the changes in CD16-56 cells and CD4/CD8 ratio were not significant (Wilk’s lambda = 0.15 and 0.94, respectively) when adjusted for BMI. In conclusion, following whole blood donation, there are transient changes in lymphocyte subsets. The effect of BMI on lymphocyte subsets and the effect of this immunomodulation on the immune response merit further investigation.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
NameEmailORCID
Borai, AnwarUNSPECIFIEDUNSPECIFIED
Livingstone, CallumC.Livingstone@surrey.ac.ukUNSPECIFIED
Alsobhi, EnaamUNSPECIFIEDUNSPECIFIED
Al sofyani, AbeerUNSPECIFIEDUNSPECIFIED
Balgoon, DalalUNSPECIFIEDUNSPECIFIED
Farzal, AnwarUNSPECIFIEDUNSPECIFIED
Almohammadi, MohammedUNSPECIFIEDUNSPECIFIED
Al-Amri, AbdulafattahUNSPECIFIEDUNSPECIFIED
Bahijri, SuhadUNSPECIFIEDUNSPECIFIED
Alrowaili, DaadUNSPECIFIEDUNSPECIFIED
Bassiuni, WafaaUNSPECIFIEDUNSPECIFIED
Saleh, AymanUNSPECIFIEDUNSPECIFIED
Alrowaili, NorahUNSPECIFIEDUNSPECIFIED
Abdelaal, MohamedUNSPECIFIEDUNSPECIFIED
Date : 20 February 2017
Identification Number : 10.1080/00365513.2017.1286520
Copyright Disclaimer : © 2017 Taylor & Francis
Uncontrolled Keywords : Blood transfusion and donation; B-lymphocyte subsets; Flow cytometry; T-lymphocyte subsets; Immunomodulation
Depositing User : Clive Harris
Date Deposited : 20 Jul 2017 08:20
Last Modified : 13 Sep 2017 11:59
URI: http://epubs.surrey.ac.uk/id/eprint/841714

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