University of Surrey

Test tubes in the lab Research in the ATI Dance Research

Subclinical left ventricular dysfunction is associated with reduced brain structure and function.

Park, Chloe, Williams, Emily, Tillin, Therese, Stuart, Robert, Chaturvedi, Nish and Hughes, Alun (2015) Subclinical left ventricular dysfunction is associated with reduced brain structure and function. In: 2015 Annual Scientific Meeting of the BHS, 21-23 Sep 2015, Stratford-upon-Avon, UK.

Full text not available from this repository.

Abstract

Background: Subclinical left ventricle (LV) dysfunction has been associated with early cognitive impairment; however findings are inconsistent. We investigated the association between LV function and both functional and structural measures of thebrain. Methods: A community-based sample 1207 individuals (69±6 yrs) underwent echocardiography and cognitive function assessment using the Community Screening Instrument for Dementia score (CSID).Hippocampal volume was measured by MRI. Fast-ing bloods including NT-pro BNP levels were measured. Measures of LV systolic and diastolic function included peak shortening velocity in systole (s’), and LA diameter (indexed to height2.7(LADI)). Results: After adjusting for age, sex and ethnicity, hippocampal volume was associated with all measures of LV function (Table 1: Model 1). CSID was significantly associated with diastolic but not systolic function. After further adjusting for diabetes, stroke, education and hypertension all significant associations remained (Table 1: Model 2). Conclusion: In a community-based sample of older people, measures of LV function were associated with functional and structural measures of cognitive impairment. These associations were not explained by concomitant risk factors.

Item Type: Conference or Workshop Item (Conference Paper)
Divisions : Faculty of Health and Medical Sciences > School of Health Sciences
Authors :
NameEmailORCID
Park, ChloeUNSPECIFIEDUNSPECIFIED
Williams, Emilye.d.williams@surrey.ac.ukUNSPECIFIED
Tillin, ThereseUNSPECIFIEDUNSPECIFIED
Stuart, RobertUNSPECIFIEDUNSPECIFIED
Chaturvedi, NishUNSPECIFIEDUNSPECIFIED
Hughes, AlunUNSPECIFIEDUNSPECIFIED
Date : October 2015
Identification Number : 10.1038/jhh.2015.90
Copyright Disclaimer : © 2015 Macmillan Publishers Limited, part of Springer Nature. All Rights Reserved.
Related URLs :
Additional Information : Session: Young Investigators Awards Session Clinical Science.
Depositing User : Clive Harris
Date Deposited : 12 Jul 2017 12:52
Last Modified : 12 Jul 2017 12:52
URI: http://epubs.surrey.ac.uk/id/eprint/841616

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year


Information about this web site

© The University of Surrey, Guildford, Surrey, GU2 7XH, United Kingdom.
+44 (0)1483 300800