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High energy resolution hyperspectral X-ray imaging for low-dose contrast-enhanced digital mammography

Pani, Silvia, Saifuddin, SC, Ferreira, Filipa, Henthorn, N, Sellers, P, Sellin, Paul, Stratmann, P, Veale, MC, Wilson, MD and Cernik, RJ (2017) High energy resolution hyperspectral X-ray imaging for low-dose contrast-enhanced digital mammography IEEE Transactions on Medical Imaging, 36 (9). pp. 1784-1795.

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Abstract

Contrast-enhanced digital mammography (CEDM) is an alternative to conventional X-ray mammography for imaging dense breasts. However, conventional approaches to CEDM require a double exposure of the patient, implying higher dose and risk of incorrect image registration due to motion artifacts. A novel approach is presented, based on hyperspectral imaging, where a detector combining positional and high-resolution spectral information (in this case based on Cadmium Telluride) is used. This allows simultaneous acquisition of the two images required for CEDM. The approach was tested on a custom breast-equivalent phantom containing iodinated contrast agent (Niopam 150®). Two algorithms were used to obtain images of the contrast agent distribution: K-edge subtraction (KES), providing images of the distribution of the contrast agent with the background structures removed, and a dual-energy (DE) algorithm, providing an iodine-equivalent image and a water-equivalent image. The high energy resolution of the detector allowed the selection of two close-by energies, maximising the signal in KES images and enhancing the visibility of details with low surface concentration of contrast agent. DE performed consistently better than KES in terms of contrast-to-noise ratio of the details; moreover, it allowed a correct reconstruction of the surface concentration of the contrast agent in the iodine image. Comparison with CEDM with a conventional detector proved the superior performance of hyperspectral CEDM in terms of the image quality/dose trade-off.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences > Physics
Authors :
NameEmailORCID
Pani, SilviaS.Pani@surrey.ac.ukUNSPECIFIED
Saifuddin, SCUNSPECIFIEDUNSPECIFIED
Ferreira, Filipaf.ferreira@surrey.ac.ukUNSPECIFIED
Henthorn, NUNSPECIFIEDUNSPECIFIED
Sellers, PUNSPECIFIEDUNSPECIFIED
Sellin, PaulP.Sellin@surrey.ac.ukUNSPECIFIED
Stratmann, PUNSPECIFIEDUNSPECIFIED
Veale, MCUNSPECIFIEDUNSPECIFIED
Wilson, MDUNSPECIFIEDUNSPECIFIED
Cernik, RJUNSPECIFIEDUNSPECIFIED
Date : 18 May 2017
Funders : EPSRC
Identification Number : 10.1109/TMI.2017.2706065
Copyright Disclaimer : © 2017 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works
Depositing User : Melanie Hughes
Date Deposited : 06 Jul 2017 09:56
Last Modified : 26 Sep 2017 13:20
URI: http://epubs.surrey.ac.uk/id/eprint/841574

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