University of Surrey

Test tubes in the lab Research in the ATI Dance Research

Night work, light exposure and melatonin on work days and days off

Daugaard, S, Garde, AH, Bonde, JPE, Christoffersen, J, Hansen, AM, Markvart, J, Schlünssen, V, Skene, Debra, Vistisen, HT and Kolstad, HA (2017) Night work, light exposure and melatonin on work days and days off Chronobiology International.

[img] Text
Night work light and melatonin_clean version.docx - Accepted version Manuscript
Restricted to Repository staff only

Download (47kB)
[img] Text
Figure 1_.docx - Accepted version Manuscript
Restricted to Repository staff only

Download (81kB)
[img] Text
Table 1_.docx - Accepted version Manuscript
Restricted to Repository staff only

Download (12kB)
[img] Text
Table 2_.docx - Accepted version Manuscript
Restricted to Repository staff only

Download (13kB)
[img] Text
Table 3_.docx - Accepted version Manuscript
Restricted to Repository staff only

Download (15kB)
[img] Text
Table 4_.docx - Accepted version Manuscript
Restricted to Repository staff only

Download (16kB)
[img] Text
Table 5_.docx - Accepted version Manuscript
Restricted to Repository staff only

Download (13kB)
[img] Text
Table 6_.docx - Accepted version Manuscript
Restricted to Repository staff only

Download (12kB)
[img] Text
Table 7_.docx - Accepted version Manuscript
Restricted to Repository staff only

Download (13kB)

Abstract

We aimed to examine the effects of night work on salivary melatonin concentration during and subsequent to night work and the mediating role of light. We included 254 day workers and 87 night workers who were followed during 322 work days and 301 days off work. Each day was defined as the 24 hour period starting from the beginning of a night shift or from waking in the mornings with day work and days off. Light levels were recorded and synchronized with diary information (start and end of sleep and work). On average, participants provided four saliva samples per day, and these were analyzed for melatonin concentration by liquid chromatography tandem mass spectrometry (LC-MS/MS). Differences between day and night workers on work days and days off were assessed with multilevel regression models with melatonin concentration as the primary outcome. All models were stratified or adjusted by time of day. For light exposure, we estimated the total, direct and indirect effects of night work on melatonin concentrations obtaining 95% confidence intervals through bootstrapping. On work days, night workers showed 15% lower salivary melatonin concentrations compared with day workers (−15.0%; 95% CI: −31.4%; 5.2%). During the night, light exposure mediated a melatonin suppression of approximately 6% (−5.9%, 95% CI: −10.2%; −1.5%). No mediating effect of light was seen during the day time. On days off, we observed no difference in melatonin concentrations between day and night workers. These findings are in accordance with a transient and partly light-mediated effect of night work on melatonin production.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
NameEmailORCID
Daugaard, SUNSPECIFIEDUNSPECIFIED
Garde, AHUNSPECIFIEDUNSPECIFIED
Bonde, JPEUNSPECIFIEDUNSPECIFIED
Christoffersen, JUNSPECIFIEDUNSPECIFIED
Hansen, AMUNSPECIFIEDUNSPECIFIED
Markvart, JUNSPECIFIEDUNSPECIFIED
Schlünssen, VUNSPECIFIEDUNSPECIFIED
Skene, DebraD.Skene@surrey.ac.ukUNSPECIFIED
Vistisen, HTUNSPECIFIEDUNSPECIFIED
Kolstad, HAUNSPECIFIEDUNSPECIFIED
Date : 14 June 2017
Identification Number : https://doi.org/10.1080/07420528.2017.1327867
Copyright Disclaimer : This is an Accepted Manuscript of an article published by Taylor & Francis in Chronobiology International on 14 June 2017, available online: http://www.tandfonline.com/10.1080/07420528.2017.1327867
Uncontrolled Keywords : Night Work, melatonin suppression, light exposure, field study
Depositing User : Melanie Hughes
Date Deposited : 23 Jun 2017 08:45
Last Modified : 23 Jun 2017 08:55
URI: http://epubs.surrey.ac.uk/id/eprint/841476

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year


Information about this web site

© The University of Surrey, Guildford, Surrey, GU2 7XH, United Kingdom.
+44 (0)1483 300800