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Decreased Firing of Striatal Neurons Related to Licking during Acquisition and Overtraining of a Licking Task

Tang, Chris C, Root, David H, Duke, Dawn, Zhu, Yun, Teixeria, Kate, Ma, Sisi, Barker, David J and West, Mark O (2009) Decreased Firing of Striatal Neurons Related to Licking during Acquisition and Overtraining of a Licking Task The Journal of Neuroscience,, 29 (44). pp. 13952-13961.

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Abstract

Neurons that fire in relation to licking, in the ventral part of the dorsolateral striatum (DLS), were studied during acquisition and performance of a licking task in rats for 14 sessions (2 h/d). Task learning was indicated by fewer errors of omission of licking and improved movement efficiency (i.e., shorter lick duration) over sessions. Number of licks did not change over sessions. Overtraining didnot result in habit formation, as indicated by similar reductions of licking responses following devaluation by satiety in both early and latesessions. Twenty-nine lick neurons recorded and tracked over sessions exhibited a significant linear decrease in average firing rate across all neurons over sessions, correlating with concurrent declines in lick duration. Individually, most neurons (86%) exhibited decreased firing rates, while a small proportion (14%) exhibited increased firing rates, during lick movements that were matched over sessions. Reward manipulations did not alter firing patterns over sessions. Aside from the absence of habit formation, striatal processing during unconditioned movements (i.e., licking) was characterized by high activity of movement-related neurons during early performance and decreased activity of the same neurons during overtraining, similar to our previous report of head movement neurons during acquired,skilled, instrumental head movements that ultimately became habitual (Tang et al., 2007). Decreased activity in DLS neurons may reflect a common neural mechanism underlying improvement in movement efficiency with overtraining. Nonetheless, the decreased striatalfiring in relation to a movement that did not become habitual demonstrates that not all DLS changes reflect habit formation.

Item Type: Article
Divisions : Researcher Development Programme
Authors :
NameEmailORCID
Tang, Chris CUNSPECIFIEDUNSPECIFIED
Root, David HUNSPECIFIEDUNSPECIFIED
Duke, DawnD.Duke@surrey.ac.ukUNSPECIFIED
Zhu, YunUNSPECIFIEDUNSPECIFIED
Teixeria, KateUNSPECIFIEDUNSPECIFIED
Ma, SisiUNSPECIFIEDUNSPECIFIED
Barker, David JUNSPECIFIEDUNSPECIFIED
West, Mark OUNSPECIFIEDUNSPECIFIED
Date : 4 November 2009
Copyright Disclaimer : Copyright©2009 Society for Neuroscience
Depositing User : Jane Hindle
Date Deposited : 23 Jun 2017 09:13
Last Modified : 23 Jun 2017 09:13
URI: http://epubs.surrey.ac.uk/id/eprint/841475

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