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Selenium, selenoproteins and selenometabolites in mother and baby at time of birth.

Santos, C, García-Fuentes, E, Callejón-Leblic, B, García-Barrera, T, Gómez-Ariza, JL, Rayman, Margaret and Velasco, I (2017) Selenium, selenoproteins and selenometabolites in mother and baby at time of birth. British Journal of Nutrition, 117 (9). pp. 1304-1311.

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Abstract

The deficiency of Se, an essential micronutrient, has been implicated in adverse pregnancy outcomes. Our study was designed to determine total serum Se, selenoproteins (extracellular glutathione peroxidase (GPx-3), selenoprotein P (SeP)), selenoalbumin (SeAlb) and selenometabolites in healthy women and their newborns at delivery. This cross-sectional study included eighty-three healthy mother–baby couples. Total Se and Se species concentrations were measured in maternal and umbilical cord sera by an in-series coupling of two-dimensional size-exclusion and affinity HPLC. Additional measurements of serum SeP concentration and of serum GPx-3 enzyme activity were carried out using ELISA. Total Se concentration was significantly higher in maternal serum than in cord serum (68·9 (sd 15·2) and 56·1 (sd 14·6) µg/l, respectively; P<0·01). There were significant correlations between selenoprotein and SeAlb concentrations in mothers and newborns, although they also showed significant differences in GPx-3 (11·2 (sd 3·7) v. 10·5 (sd 3·5) µg/l; P<0·01), SeP (42·5 (sd 9·5) v. 28·1 (sd 7·7) µg/l; P<0·01) and SeAlb (11·6 (sd 3·6) v. 14·1 (sd 4·3) µg/l; P<0·01) concentrations in maternal and cord sera, respectively. Serum GPx-3 activity and concentration were positively correlated in mothers (r 0·33; P=0·038) but not in newborns. GPx-3 activity in cord serum was significantly correlated with gestational age (r 0·44; P=0·009). SeAlb concentration was significantly higher in babies, whereas SeP and GPx-3 concentrations were significantly higher in mothers. The differences cannot be explained by simple diffusion; specific transfer mechanisms are probably involved. GPx-3 concentrations in mothers, at delivery, are related to maternal Se status, whereas the GPx-3 activity in cord serum depends on gestational age.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
NameEmailORCID
Santos, CUNSPECIFIEDUNSPECIFIED
García-Fuentes, EUNSPECIFIEDUNSPECIFIED
Callejón-Leblic, BUNSPECIFIEDUNSPECIFIED
García-Barrera, TUNSPECIFIEDUNSPECIFIED
Gómez-Ariza, JLUNSPECIFIEDUNSPECIFIED
Rayman, MargaretM.Rayman@surrey.ac.ukUNSPECIFIED
Velasco, IUNSPECIFIEDUNSPECIFIED
Date : 23 May 2017
Identification Number : 10.1017/S0007114517001155
Copyright Disclaimer : COPYRIGHT: © The Authors 2017. Published by Cambridge University Press. This is the author's manuscript of Santos, C., García-Fuentes, E., Callejón-Leblic, B., García-Barrera, T., Gómez-Ariza, J., Rayman, M., & Velasco, I. (2017). Selenium, selenoproteins and selenometabolites in mothers and babies at the time of birth. British Journal of Nutrition, 1-8. doi:10.1017/S0007114517001155 as accepted for publication after peer review. The final published version is available at: https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/selenium-selenoproteins-and-selenometabolites-in-mothers-and-babies-at-the-time-of-birth/CB9FFB9C9E27E06234202A572492D4A7
Uncontrolled Keywords : selenium; selenoproteins; SeP; gestation.
Depositing User : Melanie Hughes
Date Deposited : 30 May 2017 15:51
Last Modified : 28 Sep 2017 10:57
URI: http://epubs.surrey.ac.uk/id/eprint/841232

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