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The effect of system geometry and dose on the threshold detectable calcification diameter in 2D-mammography and digital breast tomosynthesis

Hadjipanteli, A, Elangovan, P, Mackenzie, A, Looney, PT, Wells, K, Dance, DR and Young, KC (2017) The effect of system geometry and dose on the threshold detectable calcification diameter in 2D-mammography and digital breast tomosynthesis PHYSICS IN MEDICINE AND BIOLOGY, 62 (3). pp. 858-877.

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Digital breast tomosynthesis (DBT) is under consideration to replace or to be used in combination with 2D-mammography in breast screening. The aim of this study was the comparison of the detection of microcalcification clusters by human observers in simulated breast images using 2D-mammography, narrow angle (15°/15 projections) and wide angle (50°/25 projections) DBT. The effects of the cluster height in the breast and the dose to the breast on calcification detection were also tested. Simulated images of 6 cm thick compressed breasts were produced with and without microcalcification clusters inserted, using a set of image modelling tools for 2D-mammography and DBT. Image processing and reconstruction were performed using commercial software. A series of 4-alternative forced choice (4AFC) experiments was conducted for signal detection with the microcalcification clusters as targets. Threshold detectable calcification diameter was found for each imaging modality with standard dose: 2D-mammography: 2D-mammography (165 ± 9 µm), narrow angle DBT (211 ± 11 µm) and wide angle DBT (257 ± 14 µm). Statistically significant differences were found when using different doses, but different geometries had a greater effect. No differences were found between the threshold detectable calcification diameters at different heights in the breast. Calcification clusters may have a lower detectability using DBT than 2D imaging.

Item Type: Article
Subjects : Physics
Divisions : Faculty of Engineering and Physical Sciences > Electronic Engineering > Centre for Vision Speech and Signal Processing
Authors :
Date : 10 January 2017
Identification Number : 10.1088/1361-6560/aa4f6e
Copyright Disclaimer : © 2017 Institute of Physics and Engineering in Medicine
Uncontrolled Keywords : mammography, tomosynthesis, microcalcifications
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 13:58
Last Modified : 23 May 2017 12:36

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