University of Surrey

Test tubes in the lab Research in the ATI Dance Research

Modelling release of nitric oxide in a slice of rat’s brain: describing stimulated functional hyperemia with diffusion-reaction equations.

Oleinick, AI, Amatore, C, Guille, M, Arbault, S, Klymenko, OV and Svir, I (2006) Modelling release of nitric oxide in a slice of rat’s brain: describing stimulated functional hyperemia with diffusion-reaction equations. Math Med Biol, 23 (1). pp. 27-44.

Full text not available from this repository.

Abstract

The physicochemical process of nitric oxide (NO degrees ) release from an active neuron is modelled based on the results obtained experimentally in independent series of experiments reported elsewhere in which the NO degrees release elicited by patch-clamping a single neuron (stellate neuron from cerebellum area) is monitored by an ultramicroelectrode introduced into a slice of living rat’s brain. This process is believed to be central to brain behaviour by coupling neuronal activity with the blood supply to active areas of the living brain through precise control of NO degrees -mediated dilatation of blood capillary vessels. This work, based on the conformal mapping approach initially proposed in a previous work, aims to model the overall physicochemical and diffusional processes giving rise to the release of NO degrees by a neuron and during its collection at an electrode sensor. Fitting simulated currents to experimental ones published previously yields indeed the gross kinetic information which represents the overall neuron activation and defines the instant value of the concentration of NO degrees at the neuron surface. This allows reconstructing the NO degrees fluxes around the neuron body as they would have been in the absence of the electrode sensor. This permits one to appreciate how far NO degrees is released by the neuron at concentrations which greatly exceed their basal values. The success of this procedure is exemplified using a set of three experimental data reported elsewhere.

Item Type: Article
Authors :
NameEmailORCID
Oleinick, AIUNSPECIFIEDUNSPECIFIED
Amatore, CUNSPECIFIEDUNSPECIFIED
Guille, MUNSPECIFIEDUNSPECIFIED
Arbault, SUNSPECIFIEDUNSPECIFIED
Klymenko, OVo.klymenko@surrey.ac.ukUNSPECIFIED
Svir, IUNSPECIFIEDUNSPECIFIED
Date : March 2006
Identification Number : https://doi.org/10.1093/imammb/dql001
Uncontrolled Keywords : Animals, Brain, Computer Simulation, Hyperemia, Models, Neurological, Nitrergic Neurons, Nitric Oxide, Rats
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 13:57
Last Modified : 17 May 2017 15:14
URI: http://epubs.surrey.ac.uk/id/eprint/840930

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year


Information about this web site

© The University of Surrey, Guildford, Surrey, GU2 7XH, United Kingdom.
+44 (0)1483 300800