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Attrition of paracetamol and aspirin under bulk shear deformation

Hare, C and Ghadiri, M (2015) Attrition of paracetamol and aspirin under bulk shear deformation CHEMICAL ENGINEERING SCIENCE, 125. pp. 13-19.

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Abstract

Particles are frequently exposed to shear stresses during manufacturing, which leads to breakage. This is particularly relevant to weak active pharmaceutical ingredients and is prevalent in pharmaceutical and food industries. The attrition of Paracetamol and Aspirin caused by shear deformation at very low stresses is investigated here. The extent of breakage of these particles is related to the prevailing shear stresses and strains. In contrast to the expected trend, smaller particles exhibited increased breakage rates. At the onset of shearing at low stresses Aspirin particles experienced slightly more breakage than the Paracetamol, however prolonged shearing resulted in greater breakage of Paracetamol. Breakage occurred initially through chipping with some fragmentation, particularly more noticeable for Aspirin, with an increase in abrasion after extensive shear strain for Paracetamol. Empirical breakage relationships are proposed and when combined with process stresses and strain analyses the extent of breakage occurring in process equipment can be estimated.

Item Type: Article
Divisions : Faculty of Engineering and Physical Sciences > Chemical and Process Engineering
Authors :
NameEmailORCID
Hare, Cc.hare@surrey.ac.ukUNSPECIFIED
Ghadiri, MUNSPECIFIEDUNSPECIFIED
Date : 24 March 2015
Identification Number : 10.1016/j.ces.2014.10.027
Copyright Disclaimer : © 2015. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Uncontrolled Keywords : Science & Technology, Technology, Engineering, Chemical, Engineering, Attrition, Breakage, Shear deformation, Particle, Chipping, Fragmentation, PARTICLE ATTRITION, SOLIDS, STRENGTH, BEHAVIOR, FAILURE, SHAPE, CELL
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 13:48
Last Modified : 04 Aug 2017 11:22
URI: http://epubs.surrey.ac.uk/id/eprint/840418

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