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Detection of cell-cyclic elements in mis-sampled gene expression data using a robust capon estimator

Bowles, T, Jakobsson, A and Chambers, J (2004) Detection of cell-cyclic elements in mis-sampled gene expression data using a robust capon estimator ICASSP, IEEE International Conference on Acoustics, Speech and Signal Processing - Proceedings, 5.

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Abstract

We present a method for the estimation of possible cell cyclic elements in mis-sampled microarray data. Accurate assessment of the frequency content of microarray data gives insight into genes which could be cell-cycle regulated. Cell cycle regulation is one component of the complex network of genetic regulatory processes and is especially relevant to the study of cancer. As cDNA microarray experiments involve human sampling of cell populations, slight variations in the sampling times invariably occur. Here, we propose estimating the frequency content of microarray data using the recent robust Capon estimator, and formulate a suitable uncertainty region to minimize over. The estimator is shown to yield robust estimates with real microarray data and to identify cell-cyclic genes that elude both the traditional Periodogram and the Capon spectral estimator.

Item Type: Article
Authors :
NameEmailORCID
Bowles, TUNSPECIFIEDUNSPECIFIED
Jakobsson, AUNSPECIFIEDUNSPECIFIED
Chambers, Jj.a.chambers@surrey.ac.ukUNSPECIFIED
Date : 27 September 2004
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 13:27
Last Modified : 17 May 2017 13:27
URI: http://epubs.surrey.ac.uk/id/eprint/839256

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