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Relation between apolipoprotein E genotype, hepatitis B virus status, and thyroid status in a sample of older persons with Down syndrome.

Percy, ME, Potyomkina, Z, Dalton, AJ, Fedor, B, Mehta, P, Andrews, DF, Mazzulli, T, Murk, L, Warren, AC, Wallace, RA , Chau, H, Jeng, W, Moalem, S, O'Brien, L, Schellenberger, S, Tran, H and Wu, L (2003) Relation between apolipoprotein E genotype, hepatitis B virus status, and thyroid status in a sample of older persons with Down syndrome. Am J Med Genet A, 120A (2). pp. 191-198.

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Abstract

Dementia of the Alzheimer type (DAT) is common in older persons with Down syndrome (DS). There are three common alleles of the apolipoprotein E (ApoE) gene (Sigma 2, Sigma 3, and Sigma 4) resulting in three different isoforms (E2, E3, and E4) and six different genotypes (2,2; 2,3; 2,4; 3,3; 3,4; and 4,4). Sigma 4 is a risk factor for DAT whereas Sigma 2 appears prophylactic. As hepatitis B virus (HBV) infection and hypothyroidism also are common in DS, we evaluated associations between ApoE type, HBV status, and thyroid status in a sample of older persons with DS (n = 55; mean age, 44.3 +/- 10.8 years) using chi-squared analysis. Participants were classified as E2 (2,2 or 2,3), E3 (3,3), or E4 (3,4 or 4,4); positive for markers of HBV infection in the present or past (i.e., total HBcAb+ and/or HBsAg+ with or without infectivity, defined as HBV+) or negative for markers of HBV infection (defined as HBV-) and, currently receiving thyroid hormone supplement (defined as "hypothyroidism") or having normal thyroid function. The majority of the HBV+ were currently HBcAb+ and HBsAb+, but not HBsAg+. In females, there was an ApoE allele effect on thyroid status (P < or = 0.01), E2 being negatively (P < or = 0.01) and E4 being positively (P < or = 0.05) associated with "hypothyroidism". There was no evidence for an ApoE allele effect on thyroid status in males. There was no evidence for an ApoE allele effect on HBV status, or for an HBV status effect on thyroid status. As thyroid status can affect cognitive function, ApoE allele effects in DAT may, in part, be thyroid effects.

Item Type: Article
Authors :
NameEmailORCID
Percy, MEUNSPECIFIEDUNSPECIFIED
Potyomkina, ZUNSPECIFIEDUNSPECIFIED
Dalton, AJa.dalton@surrey.ac.ukUNSPECIFIED
Fedor, BUNSPECIFIEDUNSPECIFIED
Mehta, PUNSPECIFIEDUNSPECIFIED
Andrews, DFUNSPECIFIEDUNSPECIFIED
Mazzulli, TUNSPECIFIEDUNSPECIFIED
Murk, LUNSPECIFIEDUNSPECIFIED
Warren, ACUNSPECIFIEDUNSPECIFIED
Wallace, RAUNSPECIFIEDUNSPECIFIED
Chau, HUNSPECIFIEDUNSPECIFIED
Jeng, WUNSPECIFIEDUNSPECIFIED
Moalem, SUNSPECIFIEDUNSPECIFIED
O'Brien, LUNSPECIFIEDUNSPECIFIED
Schellenberger, SUNSPECIFIEDUNSPECIFIED
Tran, HUNSPECIFIEDUNSPECIFIED
Wu, LUNSPECIFIEDUNSPECIFIED
Date : 15 July 2003
Identification Number : 10.1002/ajmg.a.20099
Uncontrolled Keywords : Adult, Apolipoproteins E, Down Syndrome, Female, Genotype, Hepatitis B, Hepatitis B Antibodies, Hepatitis B Surface Antigens, Hepatitis B virus, Humans, Hypothyroidism, Male, Middle Aged, Protein Isoforms, Sex Factors, Thyroid Gland, Thyrotropin
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 13:11
Last Modified : 17 May 2017 15:09
URI: http://epubs.surrey.ac.uk/id/eprint/838253

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