University of Surrey

Test tubes in the lab Research in the ATI Dance Research

Radiobiology at ultra-high dose rates employing laser-driven ions

Hanton, F, Doria, D, Kakolee, KF, Kar, S, Litt, SK, Fiorini, F, Ahmed, H, Green, S, Jeynes, JCG, Kavanagh, J , Kirby, D, Kirkby, KJ, Lewis, CL, Merchant, MJ, Nersisyan, G, Prasad, R, Prise, KM, Schettino, G, Zepf, M and Borghesi, M (2013) Radiobiology at ultra-high dose rates employing laser-driven ions Proceedings of SPIE - The International Society for Optical Engineering, 8779.

Full text not available from this repository.

Abstract

The potential that laser based particle accelerators offer to solve sizing and cost issues arising with conventional proton therapy has generated great interest in the understanding and development of laser ion acceleration, and in investigating the radiobiological effects induced by laser accelerated ions. Laser-driven ions are produced in bursts of ultra-short duration resulting in ultra-high dose rates, and an investigation at Queen's University Belfast was carried out to investigate this virtually unexplored regime of cell rdaiobiology. This employed the TARANIS terawatt laser producing protons in the MeV range for proton irradiation, with dose rates exceeding 109 Gys-1 on a single exposure. A clonogenic assay was implemented to analyse the biological effect of proton irradiation on V79 cells, which, when compared to data obtained with the same cell line irradiated with conventionally accelerated protons, was found to show no significant difference. A Relative Biological effectiveness of 1.4±0.2 at 10 % Survival Fraction was estimated from a comparison with a 225 kVp X-ray source. © 2013 SPIE.

Item Type: Article
Authors :
NameEmailORCID
Hanton, FUNSPECIFIEDUNSPECIFIED
Doria, DUNSPECIFIEDUNSPECIFIED
Kakolee, KFUNSPECIFIEDUNSPECIFIED
Kar, SUNSPECIFIEDUNSPECIFIED
Litt, SKUNSPECIFIEDUNSPECIFIED
Fiorini, FUNSPECIFIEDUNSPECIFIED
Ahmed, HUNSPECIFIEDUNSPECIFIED
Green, SUNSPECIFIEDUNSPECIFIED
Jeynes, JCGj.c.jeynes@surrey.ac.ukUNSPECIFIED
Kavanagh, JUNSPECIFIEDUNSPECIFIED
Kirby, DUNSPECIFIEDUNSPECIFIED
Kirkby, KJUNSPECIFIEDUNSPECIFIED
Lewis, CLUNSPECIFIEDUNSPECIFIED
Merchant, MJm.merchant@surrey.ac.ukUNSPECIFIED
Nersisyan, GUNSPECIFIEDUNSPECIFIED
Prasad, RUNSPECIFIEDUNSPECIFIED
Prise, KMUNSPECIFIEDUNSPECIFIED
Schettino, GUNSPECIFIEDUNSPECIFIED
Zepf, MUNSPECIFIEDUNSPECIFIED
Borghesi, MUNSPECIFIEDUNSPECIFIED
Date : 1 August 2013
Identification Number : 10.1117/12.2017565
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 12:57
Last Modified : 17 May 2017 15:07
URI: http://epubs.surrey.ac.uk/id/eprint/837392

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year


Information about this web site

© The University of Surrey, Guildford, Surrey, GU2 7XH, United Kingdom.
+44 (0)1483 300800