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NMR study of the effect of disaccharides on the stability of vesicles of phosphatidylcholine at low temperatures

Rodin, VV and Izmajlova, VN (1994) NMR study of the effect of disaccharides on the stability of vesicles of phosphatidylcholine at low temperatures Kolloidnyj Zhurnal, 56 (6). pp. 833-839.

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Abstract

Effect of disaccharides on the stability of lyophilic colloid systems (vesicles of phosphatidylcholine) at low temperatures was studied using 2H-NMR spectroscopy. Two programs of vesicles treatment were used: ′cooling down to -30°C - heating at room temperature′ and ′cooling down to -196°C - drying - rehydration′. It was shown that NMR spectra of treated vesicles totally disappeared indicating the decomposition of bilayer. The presence of disaccharides in vesicles dispersions during their treatment prevented the disappearance of the spectra. Optimum concentrations of disaccharides for the formation of safe layer around the vesicles were calculated. It was suggested that the safe properties of disaccharides were caused by their binding with membrane surface and action to water structure.

Item Type: Article
Authors :
NameEmailORCID
Rodin, VVv.rodin@surrey.ac.ukUNSPECIFIED
Izmajlova, VNUNSPECIFIEDUNSPECIFIED
Date : 1 November 1994
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 12:48
Last Modified : 17 May 2017 12:48
URI: http://epubs.surrey.ac.uk/id/eprint/836802

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