Dosimetric consequences of inter-fraction breathing-pattern variation on radiotherapy with personalized motion-assessed margins.

Kavanagh, A, McQuaid, D, Evans, P, Webb, S and Guckenberger, M (2011) Dosimetric consequences of inter-fraction breathing-pattern variation on radiotherapy with personalized motion-assessed margins. Phys Med Biol, 56 (22). pp. 7033-7043.

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Abstract

The data from eight patients who had undergone stereotactic body radiotherapy were selected due to their 4D-CT planning scans showing that their tumours had respiratory induced motion trajectories of large amplitude (greater than 9 mm in cranio-caudal direction). Radiotherapy plans with personalized motion-assessed margins were generated for these eight patients. The margins were generated by inverse 4D planning on an eight-bin phase-sorted 4D-CT scan. The planning was done on an in-house software system with a non-rigid registration stage being completed using freely available software. The resultant plans were then recalculated on a 4D-CT scan taken later during the course of treatment. Simulated image-guided patient set-up was used to align the geometric centres of the tumour region and minimize any misalignment between the two reconstructions. In general, the variation in the patient breathing patterns was found to be very small. Consequently, the degradation of the mean dose to the tumour region was found to be around a few percent (<3%) and hence was not a large effect.

Item Type:	Article
Authors :	Name Email ORCID Kavanagh, A McQuaid, D Evans, P p.evans@surrey.ac.uk Webb, S Guckenberger, M
Date :	21 November 2011
Identification Number :	10.1088/0031-9155/56/22/003
Uncontrolled Keywords :	Adult, Artifacts, Carcinoma, Non-Small-Cell Lung, Four-Dimensional Computed Tomography, Humans, Motion, Radiometry, Radiotherapy Dosage, Radiotherapy Planning, Computer-Assisted, Respiration, Software
Related URLs :	Author
Depositing User :	Symplectic Elements
Date Deposited :	17 May 2017 12:44
Last Modified :	17 May 2017 15:05
URI:	http://epubs.surrey.ac.uk/id/eprint/836557

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