Biological cell irradiation at ultrahigh dose rate employing laser driven protons

Doria, D, Kakolee, KF, Kar, S, Litt, SK, Fiorini, F, Ahmed, H, Green, S, Jeynes, JG, Kavanagh, J, Kirby, D et al, Kirkby, KJ, Lewis, CL, Merchant, MJ, Nersisyan, G, Prasad, R, Prise, KM, Schettino, G, Zepf, M and Borghesi, M (2012) Biological cell irradiation at ultrahigh dose rate employing laser driven protons AIP Conference Proceedings, 1462. pp. 135-138.

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Abstract

The ultrashort duration of laser-driven multi-MeV ion bursts offers the possibility of radiobiological studies at extremely high dose rates. Employing the TARANIS Terawatt laser at Queen's University, the effect of proton irradiation at MeV-range energies on live cells has been investigated at dose rates exceeding 109Gy/s as a single exposure. A clonogenic assay showed consistent lethal effects on V-79 live cells, which, even at these dose rates, appear to be in line with previously published results employing conventional sources. A Relative Biological Effectiveness (RBE) of 1.4±0.2 at 10% survival is estimated from a comparison with a 225 kVp X-ray source. © 2012 American Institute of Physics.

Item Type:	Article
Authors :	Name Email ORCID Doria, D Kakolee, KF Kar, S Litt, SK Fiorini, F Ahmed, H Green, S Jeynes, JG Kavanagh, J Kirby, D Kirkby, KJ Lewis, CL Merchant, MJ m.merchant@surrey.ac.uk Nersisyan, G Prasad, R Prise, KM Schettino, G Zepf, M Borghesi, M
Date :	1 December 2012
DOI :	10.1063/1.4736777
Depositing User :	Symplectic Elements
Date Deposited :	17 May 2017 12:42
Last Modified :	17 May 2017 12:42
URI:	http://epubs.surrey.ac.uk/id/eprint/836394

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