Biological cell irradiation at ultrahigh dose rate employing laser driven protons

Doria, D, Kakolee, KF, Kar, S, Litt, SK, Fiorini, F, Ahmed, H, Green, S, Jeynes, JG, Kavanagh, J, Kirby, D, Kirkby, KJ, Lewis, CL, Merchant, MJ, Nersisyan, G, Prasad, R, Prise, KM, Schettino, G, Zepf, M and Borghesi, M (2012) Biological cell irradiation at ultrahigh dose rate employing laser driven protons AIP Conference Proceedings, 1462. pp. 135-138.

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Abstract

The ultrashort duration of laser-driven multi-MeV ion bursts offers the possibility of radiobiological studies at extremely high dose rates. Employing the TARANIS Terawatt laser at Queen's University, the effect of proton irradiation at MeV-range energies on live cells has been investigated at dose rates exceeding 109Gy/s as a single exposure. A clonogenic assay showed consistent lethal effects on V-79 live cells, which, even at these dose rates, appear to be in line with previously published results employing conventional sources. A Relative Biological Effectiveness (RBE) of 1.4±0.2 at 10% survival is estimated from a comparison with a 225 kVp X-ray source. © 2012 American Institute of Physics.

Item Type:	Article
Authors :	Name Email ORCID Doria, D UNSPECIFIED UNSPECIFIED Kakolee, KF UNSPECIFIED UNSPECIFIED Kar, S UNSPECIFIED UNSPECIFIED Litt, SK UNSPECIFIED UNSPECIFIED Fiorini, F UNSPECIFIED UNSPECIFIED Ahmed, H UNSPECIFIED UNSPECIFIED Green, S UNSPECIFIED UNSPECIFIED Jeynes, JG UNSPECIFIED UNSPECIFIED Kavanagh, J UNSPECIFIED UNSPECIFIED Kirby, D UNSPECIFIED UNSPECIFIED Kirkby, KJ UNSPECIFIED UNSPECIFIED Lewis, CL UNSPECIFIED UNSPECIFIED Merchant, MJ m.merchant@surrey.ac.uk UNSPECIFIED Nersisyan, G UNSPECIFIED UNSPECIFIED Prasad, R UNSPECIFIED UNSPECIFIED Prise, KM UNSPECIFIED UNSPECIFIED Schettino, G UNSPECIFIED UNSPECIFIED Zepf, M UNSPECIFIED UNSPECIFIED Borghesi, M UNSPECIFIED UNSPECIFIED
Date :	1 December 2012
Identification Number :	https://doi.org/10.1063/1.4736777
Depositing User :	Symplectic Elements
Date Deposited :	17 May 2017 12:42
Last Modified :	17 May 2017 12:42
URI:	http://epubs.surrey.ac.uk/id/eprint/836394

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