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Anolignan B: a bioactive compound from the roots of Terminalia sericea.

Eldeen, IM, Elgorashi, EE, Mulholland, DA and van Staden, J (2006) Anolignan B: a bioactive compound from the roots of Terminalia sericea. J Ethnopharmacol, 103 (1). pp. 135-138.

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Abstract

Antibacterial bioassay-guided fractionation of an ethyl acetate root extract of Terminalia sericea led to the isolation of anolignan B. The isolated compound was further tested for anti-inflammatory activity using the cyclooxygenase enzyme assays (COX-1 and COX-2) and for potential mutagenic effects using the Ames test. In the antibacterial test, anolignan B showed activity against both Gram-positive and Gram-negative bacteria. The minimum inhibitory concentration values obtained (MIC) ranged from 3.8 microg/ml against Bacillus subtilis (Gram-positive) to 31 microg/ml against Escherichia coli (Gram-negative). In the anti-inflammatory assays, anolignan B showed activity against both COX-1 (IC(50) = 1.5 mM) and COX-2 (IC(50) = 7.5 mM) enzymes. No potential mutagenic effects were observed in the Salmonella microsome assay (TA98). Isolation of anolignan B from Terminalia sericea as well as the antibacterial and anti-inflammatory activities observed in this study has not been reported previously.

Item Type: Article
Authors :
NameEmailORCID
Eldeen, IMUNSPECIFIEDUNSPECIFIED
Elgorashi, EEUNSPECIFIEDUNSPECIFIED
Mulholland, DAd.mulholland@surrey.ac.ukUNSPECIFIED
van Staden, JUNSPECIFIEDUNSPECIFIED
Date : 3 January 2006
Identification Number : 10.1016/j.jep.2005.09.005
Uncontrolled Keywords : Anti-Bacterial Agents, Cyclooxygenase Inhibitors, Lignans, Mutagenicity Tests, Plant Roots, Terminalia
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 12:28
Last Modified : 17 May 2017 15:04
URI: http://epubs.surrey.ac.uk/id/eprint/835462

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