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Synthesis of amino-substituted indoles using the Bartoli reaction

Wylie, L, Innocenti, P, Whelligan, DK and Hoelder, S (2012) Synthesis of amino-substituted indoles using the Bartoli reaction Org Biomol Chem, 10 (22). pp. 4441-4447.

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Abstract

We report herein the concise preparation of a range of functionalised aminoindoles via a new application of the Bartoli reaction. Scope and limitations of the methodology have been extensively studied to reveal the importance of protecting groups and substitution patterns. The use of amino substituted nitroanilines for the Bartoli reaction is to our knowledge unprecedented. Our work thus represents a novel entry into substituted aminoindoles which are relevant building blocks for both the fine chemical and pharmaceutical industry.

Item Type: Article
Authors :
NameEmailORCID
Wylie, LUNSPECIFIEDUNSPECIFIED
Innocenti, PUNSPECIFIEDUNSPECIFIED
Whelligan, DKd.whelligan@surrey.ac.ukUNSPECIFIED
Hoelder, SUNSPECIFIEDUNSPECIFIED
Date : 14 June 2012
Identification Number : 10.1039/c2ob25256b
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 12:25
Last Modified : 17 May 2017 15:04
URI: http://epubs.surrey.ac.uk/id/eprint/835296

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