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Synthesis and characterization of gelatin fragments obtained by controlled degradation

Piluso, S, Weigel, T, Lendlein, A and Neffe, AT (2011) Synthesis and characterization of gelatin fragments obtained by controlled degradation Macromolecular Symposia, 309-31 (1). pp. 199-204.

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Abstract

Telechelic oligomers are attractive starting materials for the preparation of materials with tailorable properties. Here, peptide chains with defined molecular weight were obtained by controlled degradation of gelatin with hydroxylamine, which resulted in the cleavage of asparaginyl-glycine bonds and formation of new aspartyl hydroxamates and amino endgroups. The reaction of gelatin with hydroxylamine resulted in fragments with molecular weights of 15, 25, 37, and 50 kDa (determined by SDS-PAGE) independently of the reaction time and conditions. The fragment mixture showed typical single and triple helical organization in WAXS spectra, but rheological studies showed lower G′ and G″ values for gels from the fragment mixture than from gelatin, and lower gel-sol transitions temperatures. A more narrow distribution was found for the fragment mixture (M n = 25 kDa, PDI = 1.4) than for commercial gelatin. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Item Type: Article
Authors :
NameEmailORCID
Piluso, Ss.piluso@surrey.ac.ukUNSPECIFIED
Weigel, TUNSPECIFIEDUNSPECIFIED
Lendlein, AUNSPECIFIEDUNSPECIFIED
Neffe, ATUNSPECIFIEDUNSPECIFIED
Date : 1 December 2011
Identification Number : https://doi.org/10.1002/masy.201100054
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 12:24
Last Modified : 17 May 2017 12:24
URI: http://epubs.surrey.ac.uk/id/eprint/835179

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