Elemental and structural studies at the bone-cartilage interface

Bradley, DA, Kaabar, W and Gundogdu, O (2012) Elemental and structural studies at the bone-cartilage interface In: IX LATIN AMERICAN SYMPOSIUM ON NUCLEAR PHYSICS AND APPLICATIONS, 2011-07-18 - 2011-07-22, Quito, Ecuador.

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Abstract

The techniques μProton-Induced X-and γ-ray Emission, μ-PIXE and μ-PIGE, were used to investigate trace and essential element distributions in sections of normal and osteoarthritic (OA) human femoral head. μ-PIGE yielded 2-D mappings of Na and F while Ca, Z, P and S were mapped by μ-PIXE. The concentration of chondroitin sulphate supporting functionality in healthy cartilage is significantly reduced in OA samples. Localised Zn points to osteoblastic/osteoclastic activity at the bone-cartilage interface. Small-angle X-ray scattering applied to decalcified OA-affected tissue showed spatial alterations of collagen fibres of decreased axial periodicity compared to normal collagen type I.

Item Type:	Conference or Workshop Item (UNSPECIFIED)
Authors :	Name Email ORCID Bradley, DA d.a.bradley@surrey.ac.uk Kaabar, W Gundogdu, O
Date :	2012
DOI :	10.1063/1.3688820
Contributors :	Contribution Name Email ORCID publisher American Institute of Physics,
Depositing User :	Symplectic Elements
Date Deposited :	17 May 2017 12:23
Last Modified :	19 Jun 2018 06:11
URI:	http://epubs.surrey.ac.uk/id/eprint/835140

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