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Elemental and structural studies at the bone-cartilage interface

Bradley, DA, Kaabar, W and Gundogdu, O (2012) Elemental and structural studies at the bone-cartilage interface In: IX LATIN AMERICAN SYMPOSIUM ON NUCLEAR PHYSICS AND APPLICATIONS, 2011-07-18 - 2011-07-22, Quito, Ecuador.

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The techniques μProton-Induced X-and γ-ray Emission, μ-PIXE and μ-PIGE, were used to investigate trace and essential element distributions in sections of normal and osteoarthritic (OA) human femoral head. μ-PIGE yielded 2-D mappings of Na and F while Ca, Z, P and S were mapped by μ-PIXE. The concentration of chondroitin sulphate supporting functionality in healthy cartilage is significantly reduced in OA samples. Localised Zn points to osteoblastic/osteoclastic activity at the bone-cartilage interface. Small-angle X-ray scattering applied to decalcified OA-affected tissue showed spatial alterations of collagen fibres of decreased axial periodicity compared to normal collagen type I.

Item Type: Conference or Workshop Item (UNSPECIFIED)
Divisions : Surrey research (other units)
Authors :
Kaabar, W
Gundogdu, O
Date : 2012
DOI : 10.1063/1.3688820
Contributors :
publisherAmerican Institute of Physics,
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 12:23
Last Modified : 23 Jan 2020 17:48

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