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Modelling multiscale aspects of colorectal cancer

Van Leeuwen, IMM, Byrne, HM, Johnston, MD, Edwards, CM, Chapman, SJ, Bodmer, WF and Maini, PK (2007) Modelling multiscale aspects of colorectal cancer AIP Conference Proceedings, 971. pp. 3-7.

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Abstract

Colorectal cancer (CRC) is responsible for nearly half a million deaths annually world-wide [11]. We present a series of mathematical models describing the dynamics of the intestinal epithelium and the kinetics of the molecular pathway most commonly mutated in CRC, the Wnt signalling network. We also discuss how we are coupling such models to build a multiscale model of normal and aberrant guts. This will enable us to combine disparate experimental and clinical data, to investigate interactions between phenomena taking place at different levels of organisation and, eventually, to test the efficacy of new drugs on the system as a whole. © 2008 American Institute of Physics.

Item Type: Article
Authors :
NameEmailORCID
Van Leeuwen, IMMUNSPECIFIEDUNSPECIFIED
Byrne, HMUNSPECIFIEDUNSPECIFIED
Johnston, MDUNSPECIFIEDUNSPECIFIED
Edwards, CMUNSPECIFIEDUNSPECIFIED
Chapman, SJUNSPECIFIEDUNSPECIFIED
Bodmer, WFUNSPECIFIEDUNSPECIFIED
Maini, PKUNSPECIFIEDUNSPECIFIED
Date : 1 December 2007
Identification Number : 10.1063/1.2883865
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 12:21
Last Modified : 17 May 2017 12:21
URI: http://epubs.surrey.ac.uk/id/eprint/834998

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