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Dynamic in vivo mapping of model moisturiser ingress into human skin by GARfield MRI.

Ciampi, E, van Ginkel, M, McDonald, PJ, Pitts, S, Bonnist, EY, Singleton, S and Williamson, AM (2011) Dynamic in vivo mapping of model moisturiser ingress into human skin by GARfield MRI. NMR Biomed, 24 (2). pp. 135-144.

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We describe the development of in vivo one-dimensional MRI (profiling) using a GARField (Gradient At Right angles to Field) magnet for the characterisation of side-of-hand human skin. For the first time and in vivo, we report measurements of the NMR longitudinal and transverse relaxation parameters and self-diffusivity of the upper layers of human skin with a nominal spatial resolution better than 10 µm. The results are correlated with in vivo confocal Raman spectroscopy measurements of water concentration and natural moisturiser factors, and discussed in terms of known skin biology and microstructure of the stratum corneum and viable epidermis. The application of model moisturiser solutions to the skin is followed and their dynamics of ingress are characterised using the MRI methodology developed. Selected hydrophilic and lipophilic formulations are studied. The results are corroborated by standard in vivo measurements of transepidermal water loss and hydration status. A further insight into moisturisation mechanisms is gained. The effect of two different penetration enhancers on a commonly used skin care oil is also discussed, and different timescales of oil penetration into the skin are reported depending on the type of enhancer.

Item Type: Article
Divisions : Surrey research (other units)
Authors :
Ciampi, E
van Ginkel, M
Pitts, S
Bonnist, EY
Singleton, S
Williamson, AM
Date : February 2011
DOI : 10.1002/nbm.1562
Uncontrolled Keywords : Adult, Diffusion, Health, Humans, Magnetic Resonance Imaging, Male, Skin, Skin Physiological Phenomena, Time Factors, Water
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 11:57
Last Modified : 24 Jan 2020 21:29

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