University of Surrey

Test tubes in the lab Research in the ATI Dance Research

Dynamic in vivo mapping of model moisturiser ingress into human skin by GARfield MRI.

Ciampi, E, van Ginkel, M, McDonald, PJ, Pitts, S, Bonnist, EY, Singleton, S and Williamson, AM (2011) Dynamic in vivo mapping of model moisturiser ingress into human skin by GARfield MRI. NMR Biomed, 24 (2). pp. 135-144.

Full text not available from this repository.

Abstract

We describe the development of in vivo one-dimensional MRI (profiling) using a GARField (Gradient At Right angles to Field) magnet for the characterisation of side-of-hand human skin. For the first time and in vivo, we report measurements of the NMR longitudinal and transverse relaxation parameters and self-diffusivity of the upper layers of human skin with a nominal spatial resolution better than 10 µm. The results are correlated with in vivo confocal Raman spectroscopy measurements of water concentration and natural moisturiser factors, and discussed in terms of known skin biology and microstructure of the stratum corneum and viable epidermis. The application of model moisturiser solutions to the skin is followed and their dynamics of ingress are characterised using the MRI methodology developed. Selected hydrophilic and lipophilic formulations are studied. The results are corroborated by standard in vivo measurements of transepidermal water loss and hydration status. A further insight into moisturisation mechanisms is gained. The effect of two different penetration enhancers on a commonly used skin care oil is also discussed, and different timescales of oil penetration into the skin are reported depending on the type of enhancer.

Item Type: Article
Authors :
NameEmailORCID
Ciampi, EUNSPECIFIEDUNSPECIFIED
van Ginkel, MUNSPECIFIEDUNSPECIFIED
McDonald, PJp.mcdonald@surrey.ac.ukUNSPECIFIED
Pitts, SUNSPECIFIEDUNSPECIFIED
Bonnist, EYUNSPECIFIEDUNSPECIFIED
Singleton, SUNSPECIFIEDUNSPECIFIED
Williamson, AMUNSPECIFIEDUNSPECIFIED
Date : February 2011
Identification Number : https://doi.org/10.1002/nbm.1562
Uncontrolled Keywords : Adult, Diffusion, Health, Humans, Magnetic Resonance Imaging, Male, Skin, Skin Physiological Phenomena, Time Factors, Water
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 11:57
Last Modified : 17 May 2017 15:00
URI: http://epubs.surrey.ac.uk/id/eprint/833381

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year


Information about this web site

© The University of Surrey, Guildford, Surrey, GU2 7XH, United Kingdom.
+44 (0)1483 300800