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Distribution of the second virial coefficients of globular proteins

Sear, RP (2002) Distribution of the second virial coefficients of globular proteins Europhysics Letters, 60. pp. 938-944.

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Abstract

George and Wilson [Acta. Cryst. D 50, 361 (1994)] looked at the distribution of values of the second virial coefficient of globular proteins, under the conditions at which they crystallise. They found the values to lie within a fairly narrow range. We have defined a simple model of a generic globular protein. We then generate a set of proteins by picking values for the parameters of the model from a probability distribution. At fixed solubility, this set of proteins is found to have values of the second virial coefficient that fall within a fairly narrow range. The shape of the probability distribution of the second virial coefficient is Gaussian because the second virial coefficient is a sum of contributions from different patches on the protein surface.

Item Type: Article
Authors :
NameEmailORCID
Sear, RPr.sear@surrey.ac.ukUNSPECIFIED
Date : 11 July 2002
Identification Number : https://doi.org/10.1209/epl/i2002-00308-1
Uncontrolled Keywords : cond-mat.soft, cond-mat.soft, q-bio.BM
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 11:28
Last Modified : 17 May 2017 14:56
URI: http://epubs.surrey.ac.uk/id/eprint/831459

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