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Nucleation of the crystalline phase of proteins in the presence of semidilute non-adsorbing polymer

Sear, RP (2001) Nucleation of the crystalline phase of proteins in the presence of semidilute non-adsorbing polymer Journal of Chemical Physics.

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Abstract

Starting from a protein solution which is metastable with respect to the crystalline phase, the effect of adding semidilute non-adsorbing polymer is considered. It is found to increase the chemical potential of the protein by a few tenths of kT, which may be enough to lower the barrier to nucleation of the crystalline phase by enough to allow crystallisation. It is also shown that assuming that the polymer induces a pairwise additive attraction leads to qualitatively incorrect results.

Item Type: Article
Authors :
NameEmailORCID
Sear, RPr.sear@surrey.ac.ukUNSPECIFIED
Date : 14 February 2001
Identification Number : https://doi.org/10.1063/1.1376163
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 11:28
Last Modified : 17 May 2017 14:56
URI: http://epubs.surrey.ac.uk/id/eprint/831453

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