University of Surrey

Test tubes in the lab Research in the ATI Dance Research

Magnetization transfer ratio in Alzheimer disease: comparison with volumetric measurements.

Ridha, BH, Symms, MR, Tozer, DJ, Stockton, KC, Frost, C, Siddique, MM, Lewis, EB, MacManus, DG, Boulby, PA, Barker, GJ, Rossor, MN, Fox, NC and Tofts, PS (2007) Magnetization transfer ratio in Alzheimer disease: comparison with volumetric measurements. AJNR Am J Neuroradiol, 28 (5). pp. 965-970.

Full text not available from this repository.

Abstract

BACKGROUND AND PURPOSE: Alzheimer disease (AD) is accompanied by macroscopic atrophy on volumetric MR imaging. A few studies have also demonstrated reduction in magnetization transfer ratio (MTR), suggesting microstructural changes in remaining brain tissue. This study assessed the value of measuring MTR in addition to volumetric MR in differentiating patients with AD from control subjects. MATERIALS AND METHODS: Volumetric T1-weighted images and 3D MTR maps were obtained from 18 patients with AD and 18 age-matched control subjects. Whole-brain (WB) and total hippocampal (Hc) volumes were measured using semiautomated techniques and adjusted for total intracranial volume. Mean MTR was obtained for WB and in the Hc region. Histogram analysis was performed for WB MTR. Among patients, associations between volumetric and MTR parameters and the Mini-Mental State Examination (MMSE) were explored. RESULTS: Patients with AD had significantly reduced WB volume (P<.0001) and mean WB MTR (P=.002) and Hc volume (P<.0001) and Hc mean MTR (P<.0001) compared with control subjects. Histogram analysis of WB MTR revealed significant reduction in the 25th percentile point in patients with AD (P=.03). Both WB volume and mean MTR were independently associated with case-control status after adjusting for the other using linear regression models. However, measuring Hc mean MTR added no statistically significant discriminatory value over and above Hc volume measurement alone. Of all MR imaging parameters, only WB volume was significantly correlated with MMSE (r=0.47, P=.048). CONCLUSIONS: This study demonstrates the independent reduction of WB volume and mean MTR in AD. This suggests that the 2 parameters reflect complementary aspects of the AD pathologic lesion at macrostructural and microstructural levels.

Item Type: Article
Authors :
NameEmailORCID
Ridha, BHUNSPECIFIEDUNSPECIFIED
Symms, MRUNSPECIFIEDUNSPECIFIED
Tozer, DJUNSPECIFIEDUNSPECIFIED
Stockton, KCUNSPECIFIEDUNSPECIFIED
Frost, CUNSPECIFIEDUNSPECIFIED
Siddique, MMUNSPECIFIEDUNSPECIFIED
Lewis, EBe.lewis@surrey.ac.ukUNSPECIFIED
MacManus, DGUNSPECIFIEDUNSPECIFIED
Boulby, PAUNSPECIFIEDUNSPECIFIED
Barker, GJUNSPECIFIEDUNSPECIFIED
Rossor, MNUNSPECIFIEDUNSPECIFIED
Fox, NCUNSPECIFIEDUNSPECIFIED
Tofts, PSUNSPECIFIEDUNSPECIFIED
Date : May 2007
Uncontrolled Keywords : Aged, Alzheimer Disease, Atrophy, Brain, Cross-Sectional Studies, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Sensitivity and Specificity
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 11:16
Last Modified : 17 May 2017 14:55
URI: http://epubs.surrey.ac.uk/id/eprint/830673

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year


Information about this web site

© The University of Surrey, Guildford, Surrey, GU2 7XH, United Kingdom.
+44 (0)1483 300800