University of Surrey

Test tubes in the lab Research in the ATI Dance Research

Depression and risk of type 2 diabetes: the potential role of metabolic factors

Schmitz, N, Deschênes, SS, Burns, RJ, Smith, KJ, Lesage, A, Strychar, I, Rabasa-Lhoret, R, Freitas, C, Graham, E, Awadalla, P and Wang, JL (2016) Depression and risk of type 2 diabetes: the potential role of metabolic factors Molecular Psychiatry, 21. pp. 1726-1732.

Full text not available from this repository.

Abstract

The aim of the present study was to evaluate the interaction between depressive symptoms and metabolic dysregulations as risk factors for type 2 diabetes. The sample comprised of 2525 adults who participated in a baseline and a follow-up assessment over a 4.5-year period in the Emotional Health and Wellbeing Study (EMHS) in Quebec, Canada. A two-way stratified sampling design was used, on the basis of the presence of depressive symptoms and metabolic dysregulation (obesity, elevated blood sugar, high blood pressure, high levels of triglycerides and decreased high-density lipoprotein). A total of 87 (3.5%) individuals developed diabetes. Participants with both depressive symptoms and metabolic dysregulation had the highest risk of diabetes (adjusted odds ratio=6.61, 95% confidence interval (CI): 4.86–9.01), compared with those without depressive symptoms and metabolic dysregulation (reference group). The risk of diabetes in individuals with depressive symptoms and without metabolic dysregulation did not differ from the reference group (adjusted odds ratio=1.28, 95% CI: 0.81–2.03), whereas the adjusted odds ratio for those with metabolic dysregulation and without depressive symptoms was 4.40 (95% CI: 3.42–5.67). The Synergy Index (SI=1.52; 95% CI: 1.07–2.17) suggested that the combined effect of depressive symptoms and metabolic dysregulation was greater than the sum of individual effects. An interaction between depression and metabolic dysregulation was also suggested by a structural equation model. Our study highlights the interaction between depressive symptoms and metabolic dysregulation as a risk factor for type 2 diabetes. Early identification, monitoring and a comprehensive management approach of both conditions might be an important diabetes prevention strategy.

Item Type: Article
Subjects : Psychology
Authors :
NameEmailORCID
Schmitz, NUNSPECIFIEDUNSPECIFIED
Deschênes, SSUNSPECIFIEDUNSPECIFIED
Burns, RJUNSPECIFIEDUNSPECIFIED
Smith, KJkimberley.j.smith@surrey.ac.ukUNSPECIFIED
Lesage, AUNSPECIFIEDUNSPECIFIED
Strychar, IUNSPECIFIEDUNSPECIFIED
Rabasa-Lhoret, RUNSPECIFIEDUNSPECIFIED
Freitas, CUNSPECIFIEDUNSPECIFIED
Graham, EUNSPECIFIEDUNSPECIFIED
Awadalla, PUNSPECIFIEDUNSPECIFIED
Wang, JLUNSPECIFIEDUNSPECIFIED
Date : 23 February 2016
Identification Number : 10.1038/mp.2016.7
Copyright Disclaimer : © 2016 Macmillan Publishers Limited, part of Springer Nature.
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 10:48
Last Modified : 18 May 2017 12:44
URI: http://epubs.surrey.ac.uk/id/eprint/829301

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year


Information about this web site

© The University of Surrey, Guildford, Surrey, GU2 7XH, United Kingdom.
+44 (0)1483 300800