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Sleep and circadian rhythm disturbance in bipolar disorder

Bradley, AJ, Webb-Mitchell, R, Hazu, A, Slater, N, Middleton, BA, Gallagher, P, McAllister-Williams, H and Anderson, KN (2017) Sleep and circadian rhythm disturbance in bipolar disorder Psychological Medicine, 47 (9). pp. 1678-1689.

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Abstract

Background. Subjective reports of insomnia and hypersomnia are common in bipolar disorder (BD). It is unclear to what extent these relate to underlying circadian rhythm disturbance (CRD). In this study we aimed to objectively assess sleep and circadian rhythm in a cohort of patients with BD compared to matched controls. Method. Forty-six patients with BD and 42 controls had comprehensive sleep/circadian rhythm assessment with respiratory sleep studies, prolonged accelerometry over 3 weeks, sleep questionnaires and diaries, melatonin levels, alongside mood, psychosocial functioning and quality of life (QoL) questionnaires. Results. Twenty-three (50%) patients with BD had abnormal sleep, of whom 12 (52%) had CRD and 29% had obstructive sleep apnoea. Patients with abnormal sleep had lower 24-h melatonin secretion compared to controls and patients with normal sleep. Abnormal sleep/CRD in BD was associated with impaired functioning and worse QoL. Conclusions. BD is associated with high rates of abnormal sleep and CRD. The association between these disorders, mood and functioning, and the direction of causality, warrants further investigation.

Item Type: Article
Divisions : Faculty of Health and Medical Sciences > School of Biosciences and Medicine
Authors :
NameEmailORCID
Bradley, AJUNSPECIFIEDUNSPECIFIED
Webb-Mitchell, RUNSPECIFIEDUNSPECIFIED
Hazu, AUNSPECIFIEDUNSPECIFIED
Slater, NUNSPECIFIEDUNSPECIFIED
Middleton, BAb.middleton@surrey.ac.ukUNSPECIFIED
Gallagher, PUNSPECIFIEDUNSPECIFIED
McAllister-Williams, HUNSPECIFIEDUNSPECIFIED
Anderson, KNUNSPECIFIEDUNSPECIFIED
Date : 8 February 2017
Identification Number : 10.1017/S0033291717000186
Copyright Disclaimer : © Cambridge University Press 2017
Uncontrolled Keywords : Bipolar, circadian rhythm, cognition, melatonin, sleep
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 10:48
Last Modified : 08 Sep 2017 11:28
URI: http://epubs.surrey.ac.uk/id/eprint/829298

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