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Associations between bullous pemphigoid and primary malignant cancers: an English national record linkage study, 1999-2011

Ong, E, Goldacre, R, Hoang, U, Sinclair, R and Goldacre, M (2014) Associations between bullous pemphigoid and primary malignant cancers: an English national record linkage study, 1999-2011 Archives of Dermatological Research, 306 (1). pp. 75-80.

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Abstract

We conducted a nationwide record-linked study using all English NHS hospital admission data and mortality statistics from 1999 to 2011 to evaluate the risk of concurrent or subsequent bullous pemphigoid (BP) in a cohort of 2,873,720 individuals with malignant cancers, when compared with a reference cohort. We calculated standardised rate ratios (RRs) based on person-years at risk, comparing the observed and expected numbers of BP cases in the cancer cohort with those in the reference cohort. Overall, the cohort of people with a record of a malignant cancer was not found to be at greater risk of concurrent or subsequent BP than the cohort of people without a record of a malignant cancer (RR 0.96, 95 % CI 0.88–1.04), although elevated risks of BP were found in sub-cohorts of people with either kidney cancer, laryngeal cancer or lymphoid leukaemia. We also similarly analysed the risk of concurrent and subsequent malignant cancers in a cohort of people with a principal diagnosis of BP, and again found no increased risk as compared with the reference cohort (RR 1.00, 95 % CI 0.92–1.09).

Item Type: Article
Subjects : Medical Science
Authors :
NameEmailORCID
Ong, EUNSPECIFIEDUNSPECIFIED
Goldacre, RUNSPECIFIEDUNSPECIFIED
Hoang, Uu.hoang@surrey.ac.ukUNSPECIFIED
Sinclair, RUNSPECIFIEDUNSPECIFIED
Goldacre, MUNSPECIFIEDUNSPECIFIED
Date : January 2014
Identification Number : https://doi.org/10.1007/s00403-013-1399-5
Copyright Disclaimer : © Springer-Verlag Berlin Heidelberg 2013
Uncontrolled Keywords : Bullous pemphigoid, Malignant cancer, Risk, Association, Cohort, Kidney cancer
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 10:47
Last Modified : 18 May 2017 12:44
URI: http://epubs.surrey.ac.uk/id/eprint/829248

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