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The genome sequence of the food-borne pathogen Campylobacter jejuni reveals hypervariable sequences

Parkhill, J, Wren, BW, Mungall, K, Ketley, JM, Churcher, C, Basham, D, Chillingworth, T, Davies, RM, Feltwell, T, Holroyd, S , Jagels, K, Karlyshev, AV, Moule, S, Pallen, MJ, Penn, CW, Quail, MA, Rajandream, MA, Rutherford, KM, van Vliet, AH, Whitehead, S and Barrell, BG (2000) The genome sequence of the food-borne pathogen Campylobacter jejuni reveals hypervariable sequences Nature, 403. pp. 665-668.

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Abstract

Campylobacter jejuni, from the delta-epsilon group of proteobacteria, is a microaerophilic, Gram-negative, flagellate, spiral bacterium—properties it shares with the related gastric pathogen Helicobacter pylori. It is the leading cause of bacterial food-borne diarrhoeal disease throughout the world1. In addition, infection with C. jejuni is the most frequent antecedent to a form of neuromuscular paralysis known as Guillain–Barré syndrome2. Here we report the genome sequence of C. jejuni NCTC11168. C. jejuni has a circular chromosome of 1,641,481 base pairs (30.6% G+C) which is predicted to encode 1,654 proteins and 54 stable RNA species. The genome is unusual in that there are virtually no insertion sequences or phage-associated sequences and very few repeat sequences. One of the most striking findings in the genome was the presence of hypervariable sequences. These short homopolymeric runs of nucleotides were commonly found in genes encoding the biosynthesis or modification of surface structures, or in closely linked genes of unknown function. The apparently high rate of variation of these homopolymeric tracts may be important in the survival strategy of C. jejuni.

Item Type: Article
Subjects : Veterinary Medicine
Authors :
NameEmailORCID
Parkhill, JUNSPECIFIEDUNSPECIFIED
Wren, BWUNSPECIFIEDUNSPECIFIED
Mungall, KUNSPECIFIEDUNSPECIFIED
Ketley, JMUNSPECIFIEDUNSPECIFIED
Churcher, CUNSPECIFIEDUNSPECIFIED
Basham, DUNSPECIFIEDUNSPECIFIED
Chillingworth, TUNSPECIFIEDUNSPECIFIED
Davies, RMUNSPECIFIEDUNSPECIFIED
Feltwell, TUNSPECIFIEDUNSPECIFIED
Holroyd, SUNSPECIFIEDUNSPECIFIED
Jagels, KUNSPECIFIEDUNSPECIFIED
Karlyshev, AVUNSPECIFIEDUNSPECIFIED
Moule, SUNSPECIFIEDUNSPECIFIED
Pallen, MJUNSPECIFIEDUNSPECIFIED
Penn, CWUNSPECIFIEDUNSPECIFIED
Quail, MAUNSPECIFIEDUNSPECIFIED
Rajandream, MAUNSPECIFIEDUNSPECIFIED
Rutherford, KMUNSPECIFIEDUNSPECIFIED
van Vliet, AHa.vanvliet@surrey.ac.ukUNSPECIFIED
Whitehead, SUNSPECIFIEDUNSPECIFIED
Barrell, BGUNSPECIFIEDUNSPECIFIED
Date : 10 February 2000
Identification Number : 10.1038/35001088
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 10:47
Last Modified : 18 May 2017 12:43
URI: http://epubs.surrey.ac.uk/id/eprint/829202

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