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Pathogenesis of Helicobacter pylori infection

Kusters, JG, van Vliet, AH and Kuipers, EJ (2006) Pathogenesis of Helicobacter pylori infection Clinical Microbiology Reviews, 19 (3). pp. 449-490.

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Abstract

Helicobacter pylori is the first formally recognized bacterial carcinogen and is one of the most successful human pathogens, as over half of the world's population is colonized with this gram-negative bacterium. Unless treated, colonization usually persists lifelong. H. pylori infection represents a key factor in the etiology of various gastrointestinal diseases, ranging from chronic active gastritis without clinical symptoms to peptic ulceration, gastric adenocarcinoma, and gastric mucosa-associated lymphoid tissue lymphoma. Disease outcome is the result of the complex interplay between the host and the bacterium. Host immune gene polymorphisms and gastric acid secretion largely determine the bacterium's ability to colonize a specific gastric niche. Bacterial virulence factors such as the cytotoxin-associated gene pathogenicity island-encoded protein CagA and the vacuolating cytotoxin VacA aid in this colonization of the gastric mucosa and subsequently seem to modulate the host's immune system. This review focuses on the microbiological, clinical, immunological, and biochemical aspects of the pathogenesis of H. pylori.

Item Type: Article
Subjects : Veterinary Medicine
Authors :
NameEmailORCID
Kusters, JGUNSPECIFIEDUNSPECIFIED
van Vliet, AHa.vanvliet@surrey.ac.ukUNSPECIFIED
Kuipers, EJUNSPECIFIEDUNSPECIFIED
Date : 1 July 2006
Identification Number : https://doi.org/10.1128/CMR.00054-05
Copyright Disclaimer : Copyright © 2006 by the American Society for Microbiology.
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 10:47
Last Modified : 18 May 2017 12:43
URI: http://epubs.surrey.ac.uk/id/eprint/829197

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