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Sleep recalibrates homeostatic and associative synaptic plasticity in the human cortex

Kuhn, M, Wolf, E, Maier, JG, Mainberger, F, Feige, B, Schmid, H, Buerklin, J, Maywald, S, Mall, V, Jung, NH, Reis, J, Spiegelhalder, K, Kloeppel, S, Sterr, A, Eckert, A, Riemann, D, Normann, C and Nissen, C (2016) Sleep recalibrates homeostatic and associative synaptic plasticity in the human cortex Nature Communications, 7, 12455.

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Abstract

Sleep is ubiquitous in animals and humans, but its function remains to be further determined. The synaptic homeostasis hypothesis of sleep–wake regulation proposes a homeostatic increase in net synaptic strength and cortical excitability along with decreased inducibility of associative synaptic long-term potentiation (LTP) due to saturation after sleep deprivation. Here we use electrophysiological, behavioural and molecular indices to non-invasively study net synaptic strength and LTP-like plasticity in humans after sleep and sleep deprivation. We demonstrate indices of increased net synaptic strength (TMS intensity to elicit a predefined amplitude of motor-evoked potential and EEG theta activity) and decreased LTP-like plasticity (paired associative stimulation induced change in motor-evoked potential and memory formation) after sleep deprivation. Changes in plasma BDNF are identified as a potential mechanism. Our study indicates that sleep recalibrates homeostatic and associative synaptic plasticity, believed to be the neural basis for adaptive behaviour, in humans.

Item Type: Article
Subjects : Psychology
Authors :
NameEmailORCID
Kuhn, MUNSPECIFIEDUNSPECIFIED
Wolf, EUNSPECIFIEDUNSPECIFIED
Maier, JGUNSPECIFIEDUNSPECIFIED
Mainberger, FUNSPECIFIEDUNSPECIFIED
Feige, BUNSPECIFIEDUNSPECIFIED
Schmid, HUNSPECIFIEDUNSPECIFIED
Buerklin, JUNSPECIFIEDUNSPECIFIED
Maywald, SUNSPECIFIEDUNSPECIFIED
Mall, VUNSPECIFIEDUNSPECIFIED
Jung, NHUNSPECIFIEDUNSPECIFIED
Reis, JUNSPECIFIEDUNSPECIFIED
Spiegelhalder, KUNSPECIFIEDUNSPECIFIED
Kloeppel, SUNSPECIFIEDUNSPECIFIED
Sterr, Aa.sterr@surrey.ac.ukUNSPECIFIED
Eckert, AUNSPECIFIEDUNSPECIFIED
Riemann, DUNSPECIFIEDUNSPECIFIED
Normann, CUNSPECIFIEDUNSPECIFIED
Nissen, CUNSPECIFIEDUNSPECIFIED
Date : 23 August 2016
Identification Number : https://doi.org/10.1038/ncomms12455
Copyright Disclaimer : © The Author(s) 2016. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Uncontrolled Keywords : Circadian rhythms and sleep, Synaptic plasticity
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 10:46
Last Modified : 18 May 2017 12:43
URI: http://epubs.surrey.ac.uk/id/eprint/829142

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