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Maternal Weaning Modulates Emotional Behavior and Regulates the Gut-Brain Axis

Farshim, P, Walton, G, Chakrabarti, B, Givens, I, Saddy, D, Kitchen, I, Swann, J and Bailey, Alexis (2016) Maternal Weaning Modulates Emotional Behavior and Regulates the Gut-Brain Axis SCIENTIFIC REPORTS, 6, ARTN 21958.

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Abstract

Evidence shows that nutritional and environmental stress stimuli during postnatal period influence brain development and interactions between gut and brain. In this study we show that in rats, prevention of weaning from maternal milk results in depressive-like behavior, which is accompanied by changes in the gut bacteria and host metabolism. Depressive-like behavior was studied using the forced-swim test on postnatal day (PND) 25 in rats either weaned on PND 21, or left with their mother until PND 25 (non-weaned). Non-weaned rats showed an increased immobility time consistent with a depressive phenotype. Fluorescence in situ hybridization showed non-weaned rats to harbor significantly lowered Clostridium histolyticum bacterial groups but exhibit marked stress-induced increases. Metabonomic analysis of urine from these animals revealed significant differences in the metabolic profiles, with biochemical phenotypes indicative of depression in the non-weaned animals. In addition, non-weaned rats showed resistance to stress-induced modulation of oxytocin receptors in amygdala nuclei, which is indicative of passive stress-coping mechanism. We conclude that delaying weaning results in alterations to the gut microbiota and global metabolic profiles which may contribute to a depressive phenotype and raise the issue that mood disorders at early developmental ages may reflect interplay between mammalian host and resident bacteria.

Item Type: Article
Authors :
NameEmailORCID
Farshim, P
Walton, G
Chakrabarti, B
Givens, I
Saddy, D
Kitchen, Ii.kitchen@surrey.ac.uk
Swann, J
Bailey, AlexisA.Bailey@surrey.ac.uk
Date : 23 February 2016
Identification Number : 10.1038/srep21958
Copyright Disclaimer : This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Uncontrolled Keywords : Science & Technology, Multidisciplinary Sciences, Science & Technology - Other Topics, FORCED SWIMMING TEST, IRRITABLE-BOWEL-SYNDROME, MAJOR DEPRESSION, OPIOID RECEPTORS, GASTROINTESTINAL FUNCTION, INTESTINAL MICROBIOTA, LACTOBACILLUS STRAIN, PARKINSONS-DISEASE, COMPLEX-I, STRESS
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 10:44
Last Modified : 28 Feb 2018 12:17
URI: http://epubs.surrey.ac.uk/id/eprint/829022

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