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Minimum inhibitory and bactericidal concentrations of theaflavin and synergistic combinations with epicatechin and quercetin against clinical isolates of Stenotrophomonas maltophilia

Betts, JW, Murphy, C, Kelly, SM and Haswell, SJ (2012) Minimum inhibitory and bactericidal concentrations of theaflavin and synergistic combinations with epicatechin and quercetin against clinical isolates of Stenotrophomonas maltophilia Journal of Microbiology, Biotechnology and Food Sciences, 1 (5). pp. 1250-1258.

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Abstract

Stenotrophomonas maltophilia is an important nosocomial pathogen with intrinsic resistance to multiple antibiotics. Previous investigations have shown flavanols from black tea to possess antibacterial activity. This study describes the determination of minimum inhibitory concentrations and minimum bactericidal concentration for theaflavin independently and in formulations with the polyphenols epicatechin and quercetin against nine clinical isolates of Stenotrophomonas maltophilia and the control isolate NCTC 130141 via the microtitre assay. The results demonstrate that theaflavin has strong antibacterial activity and also shows significant synergism with epicatechin and quercetin. The minimum inhibitory concentrations of the isolates range between 200-400 ug/mL for theaflavin and 100-200 ug/mL for both theaflavin:epicatechin and theaflavin:quercetin combinations. The minimum bactericidal concentrations were discovered to be a 2 fold increase on those of the minimum inhibitory concentrations. The research highlights the potential use of polyphenols for the clinical treatment of highly antibiotic resistant bacteria.

Item Type: Article
Authors :
NameEmailORCID
Betts, JWjono.betts@surrey.ac.ukUNSPECIFIED
Murphy, CUNSPECIFIEDUNSPECIFIED
Kelly, SMUNSPECIFIEDUNSPECIFIED
Haswell, SJUNSPECIFIEDUNSPECIFIED
Date : 1 April 2012
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 10:44
Last Modified : 17 May 2017 14:52
URI: http://epubs.surrey.ac.uk/id/eprint/828997

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