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Synergistic antibacterial effects of theaflavin in combination with ampicillin against hospital isolates of Stenotrophomonas maltophilia

Betts, JW, Murphy, C, Kelly, SM and Haswell, SJ (2012) Synergistic antibacterial effects of theaflavin in combination with ampicillin against hospital isolates of Stenotrophomonas maltophilia Journal of Microbiology, Biotechnology and Food Sciences, 2 (3). pp. 1068-1078.

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Abstract

Stenotrophomonas maltophilia is an important opportunistic nosocomial pathogen that shows intrinsic resistance to many antibiotics. This often limits treatment options and can cause lengthy hospital stays. Combination treatments are often used to combat resistance and using natural compounds such as polyphenols could give increased treatment options and even the reuse of antibiotics to which high levels of resistance have been observed. A checkerboard assay was used to determine if any synergy exists between ampicillin and the polyphenol theaflavin against 9 clinical isolates and one control isolate (NCTC 13014) of S. maltophilia. It was discovered that significant synergy (P  0.05) does exist between theaflavin and ampicillin, reducing the mean MIC of ampicillin from 12.5-22.9 μg/mL in liquid culture, to 3.125-6.25 μg/mL. The FIC index was calculated to be 0.22-0.35 confirming synergy. From these results, significant potential for medical applications can be seen and further investigation is recommended.

Item Type: Article
Authors :
NameEmailORCID
Betts, JWjono.betts@surrey.ac.ukUNSPECIFIED
Murphy, CUNSPECIFIEDUNSPECIFIED
Kelly, SMUNSPECIFIEDUNSPECIFIED
Haswell, SJUNSPECIFIEDUNSPECIFIED
Date : 1 December 2012
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 10:44
Last Modified : 17 May 2017 14:52
URI: http://epubs.surrey.ac.uk/id/eprint/828996

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