University of Surrey

Test tubes in the lab Research in the ATI Dance Research

Meta-analysis, clinical trials, and transferability of research results into practice. The case of cholesterol-lowering interventions in the secondary prevention of coronary heart disease.

Marchioli, R, Marfisi, RM, Carinci, F and Tognoni, G (1996) Meta-analysis, clinical trials, and transferability of research results into practice. The case of cholesterol-lowering interventions in the secondary prevention of coronary heart disease. Arch Intern Med, 156 (11). pp. 1158-1172.

Full text not available from this repository.

Abstract

OBJECTIVE: To evaluate, in the comprehensive scenario of "evidence-based" medicine, the transferability of the results of published randomized clinical trials and meta-analyses on cholesterol-lowering interventions to clinical practice. METHOD: Overview of randomized clinical trials on cholesterol-lowering interventions in the secondary prevention of coronary heart disease. RESULTS: The present overview on secondary prevention of coronary heart disease included 34 trials with cholesterol-lowering interventions in 24968 individuals. There was a 12.5% mortality in the group that was allocated active intervention and a 17.2% mortality in the control group (risk reduction, 13%; 95% confidence interval, -19% to -6%). Coronary and cardiovascular odds of deaths were significantly reduced. No clear association was found between noncoronary mortality and cholesterol-lowering interventions. Baseline total cholesterol levels had no clear influence on total mortality. Intermediate (10%-20%) and high ( > 20%) total cholesterol reductions were associated with similar reductions in the odds of death (-23% and -30%, respectively). No conclusion could be reached for patients who were less represented in the studies (ie, women and elderly persons). Patients with more complicated baseline clinical conditions (eg, congestive heart failure) had little nonsignificant benefit from cholesterol-lowering interventions. CONCLUSIONS: The effect of cholesterol-lowering interventions at least in the secondary prevention of coronary heart disease can be considered as established, but the transferability of such results to real-life patients remains the critical, unanswered question.

Item Type: Article
Authors :
NameEmailORCID
Marchioli, RUNSPECIFIEDUNSPECIFIED
Marfisi, RMUNSPECIFIEDUNSPECIFIED
Carinci, Ff.carinci@surrey.ac.ukUNSPECIFIED
Tognoni, GUNSPECIFIEDUNSPECIFIED
Date : 10 June 1996
Uncontrolled Keywords : Anticholesteremic Agents, Cause of Death, Cholesterol, Confounding Factors (Epidemiology), Coronary Disease, Humans, Hypercholesterolemia, Meta-Analysis as Topic, Odds Ratio, Prevalence, Randomized Controlled Trials as Topic, Reproducibility of Results
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 10:42
Last Modified : 17 May 2017 10:42
URI: http://epubs.surrey.ac.uk/id/eprint/828880

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year


Information about this web site

© The University of Surrey, Guildford, Surrey, GU2 7XH, United Kingdom.
+44 (0)1483 300800