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The efficacy of tolrestat in the treatment of diabetic peripheral neuropathy. A meta-analysis of individual patient data.

Nicolucci, A, Carinci, F, Graepel, JG, Hohman, TC, Ferris, F and Lachin, JM (1996) The efficacy of tolrestat in the treatment of diabetic peripheral neuropathy. A meta-analysis of individual patient data. Diabetes Care, 19 (10). pp. 1091-1096.

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Abstract

OBJECTIVE: The aim of this meta-analysis was to review the existent evidence on the effectiveness of tolrestat in the treatment of diabetic peripheral neuropathy. RESEARCH DESIGN AND METHODS: Individual patient data on 738 subjects from the three randomized clinical trials published on this topic were analyzed using changes in motor nerve conduction velocities (NCVs) as endpoints. Nerves investigated included median, ulnar, tibial, and peroneal. RESULTS: The pooled analysis of NCV taken as a continuous measurement showed a significant treatment effect, the magnitude of this benefit being approximately equal to 1 m/s for all the nerves investigated. When looking at the proportion of patients experiencing a loss of NCV of at least 1 or 2 m/s in at least two out of the four nerves investigated, it emerged that treatment reduced by > 40% the risk of such outcomes after adjusting for patients' characteristics. The odds ratios relative to the placebo group were 1.82 (1.30-2.52) and 1.70 (1.15-2.48) for a decrease of 1 and 2 m/s, that is, placebo-treated patients have an 82 and 70% increased risk for a loss of nerve function of 1 and 2 m/s, respectively. No statistically significant difference in treatment effect emerged after stratification according to baseline motor NCV and glycated hemoglobin levels. CONCLUSIONS: After a treatment duration ranging between 24-52 weeks, patients treated with tolrestat had a reduced risk for developing nerve function loss compared with placebo-treated patients. Future long-term trials are needed to evaluate the impact of the treatment on more clinically meaningful endpoints such as the development of foot complications.

Item Type: Article
Authors :
NameEmailORCID
Nicolucci, AUNSPECIFIEDUNSPECIFIED
Carinci, Ff.carinci@surrey.ac.ukUNSPECIFIED
Graepel, JGUNSPECIFIEDUNSPECIFIED
Hohman, TCUNSPECIFIEDUNSPECIFIED
Ferris, FUNSPECIFIEDUNSPECIFIED
Lachin, JMUNSPECIFIEDUNSPECIFIED
Date : October 1996
Uncontrolled Keywords : Aldehyde Reductase, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Diabetic Neuropathies, Enzyme Inhibitors, Female, Humans, Male, Median Nerve, Middle Aged, Naphthalenes, Neural Conduction, Peroneal Nerve, Randomized Controlled Trials as Topic, Tibial Nerve, Treatment Outcome, Ulnar Nerve
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 10:42
Last Modified : 17 May 2017 10:42
URI: http://epubs.surrey.ac.uk/id/eprint/828878

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