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The mouse gene encoding the peroxisomal membrane protein 1-like protein (PXMP1-L): cDNA cloning, genomic organization and comparative expression studies

Holzinger, A, Muntau, A, Mayerhofer, P, Kammerer, S, Albet, S, Bugaut, M and Roscher, AA (1998) The mouse gene encoding the peroxisomal membrane protein 1-like protein (PXMP1-L): cDNA cloning, genomic organization and comparative expression studies FEBS Lett, 433. pp. 179-183.

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Abstract

PXMPI-L (synonyms: PMP69, P70R) is a peroxisomal protein that belongs to the ABC-transporter superfamily. Its closest homolog is the peroxisomal membrane protein 1 (PMP70). We have cloned the mouse PXMP1-L gene. It encodes a 606 amino acid protein. In contrast to the human and the rat, mouse PXMP1-L is predominantly expressed in the liver. The mouse PXMP1-L gene consists of 19 exons and spans 21 kb of genomic sequence. No obvious peroxisome proliferator response element has been found in 1.1 kb of the putative promoter region. No coordination of constitutive or fenofibrate-induced expression of PXMP1-L with other peroxisomal ABC transporters was observed so that an obligate exclusive heterodimer formation is not likely to occur. The data presented will be particularly useful for the generation of a mouse model defective in PXMP1-L in order to elucidate the yet unknown function of this protein.

Item Type: Article
Authors :
NameEmailORCID
Holzinger, AUNSPECIFIEDUNSPECIFIED
Muntau, AUNSPECIFIEDUNSPECIFIED
Mayerhofer, Pp.mayerhofer@surrey.ac.ukUNSPECIFIED
Kammerer, SUNSPECIFIEDUNSPECIFIED
Albet, SUNSPECIFIEDUNSPECIFIED
Bugaut, MUNSPECIFIEDUNSPECIFIED
Roscher, AAUNSPECIFIEDUNSPECIFIED
Date : 1998
Uncontrolled Keywords : *ATP-Binding Cassette Transporters Amino Acid Sequence Animals Blotting, Northern *Cloning, Molecular DNA, Complementary/*genetics Exons Fenofibrate/pharmacology *Gene Expression Humans Introns Liver/metabolism Membrane Proteins/chemistry/*genetics Mice Mice, Inbred C57BL Molecular Sequence Data Organ Specificity Polymerase Chain Reaction RNA, Messenger/analysis Rats Sequence Alignment
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 10:42
Last Modified : 17 May 2017 14:51
URI: http://epubs.surrey.ac.uk/id/eprint/828864

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