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Temporal and Cerebellar Brain Regions that Support both Declarative Memory Formation and Retrieval

Weis S., , Klaver P., , Reul J., , Elger C.E., and Fernández G., (2004) Temporal and Cerebellar Brain Regions that Support both Declarative Memory Formation and Retrieval Cerebral Cortex, 14 (3). pp. 256-267.

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Abstract

Using event-related fMRI, we scanned young healthy subjects while they memorized real-world photographs and subsequently tried to recognize them within a series of new photographs. We confirmed that activity in the medial temporal lobe (MTL) and inferior prefrontal cortex correlates with declarative memory formation as defined by the subsequent memory effect, stronger responses to subsequently remembered than forgotten items. Additionally, we confirmed that activity in specific regions within the parietal lobe, anterior prefrontal cortex, anterior cingulate and cerebellum correlate with recognition memory as measured by the conventional old/new effect, stronger responses for recognized old items (hits) than correctly identified new items (correct rejections). To obtain a purer measure of recognition success, we introduced two recognition effects by comparing brain responses to hits and old items misclassified as new (misses). The positive recognition effect (hits > misses) revealed prefrontal, parietal and cerebellar contributions to recognition, and in line with electrophysiological findings, the negative recognition effect (hits < misses) revealed an anterior medial temporal contribution. Finally, by inclusive masking, we identified temporal and cerebellar brain areas that support both declarative memory formation and retrieval. For matching operations during recognition, these areas may re-use representations formed and stored locally during encoding.

Item Type: Article
Authors :
NameEmailORCID
Weis S., UNSPECIFIEDUNSPECIFIED
Klaver P., UNSPECIFIEDUNSPECIFIED
Reul J., UNSPECIFIEDUNSPECIFIED
Elger C.E., UNSPECIFIEDUNSPECIFIED
Fernández G., UNSPECIFIEDUNSPECIFIED
Date : 2004
Identification Number : 10.1093/cercor/bhg125
Uncontrolled Keywords : Declarative memory, Event-related, fMRI, Memory formation, Recognition, Retrieval
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 10:41
Last Modified : 17 May 2017 10:41
URI: http://epubs.surrey.ac.uk/id/eprint/828799

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