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Intrasubject reproducibility of presurgical language lateralization and mapping using fMRI

Fernández G., , Specht K., , Weis S., , Tendolkar I., , Reuber M., , Fell J., , Klaver P., , Ruhlmann J., , Reul J., and Elger C.E., (2003) Intrasubject reproducibility of presurgical language lateralization and mapping using fMRI Neurology, 60 (6). pp. 969-975.

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Abstract

Background: fMRI is becoming a standard tool for the presurgical lateralization and mapping of brain areas involved in language processing. However, its within-subject reproducibility has yet to be fully explored. Objective: To evaluate within-test and test-retest reliability of language fMRI in consecutive patients undergoing evaluation for epilepsy surgery. Methods: Thirty-four unselected patients were investigated once (within-test reliability) and 12 patients twice (test-retest reliability). The imaging series consisted of an alternating 25-second synonym judgment condition with a 25-second letter-matching condition repeated 15 times. Reproducibility of activation maps of the first and second half of session 1 or activation maps of sessions 1 and 2 was evaluated by comparing one global and three regional lateralization indexes (Broca's area, remaining prefrontal cortex, temporoparietal area) and on a voxel-by-voxel basis (intraclass correlation coefficient, percentage overlap, correlation of t-values). Results: Global and regional language lateralization was achieved with high reliability within and across sessions. Reproducibility was evenly distributed across both hemispheres but not within each hemisphere. Frontal activations were more reliable than temporoparietal ones. Depending on the statistical threshold chosen, the voxel-by-voxel analysis revealed a mean overlap of activations derived from the first and second investigation of up to 48.9%. Conclusion: Language fMRI proved sufficiently reliable for the determination of global and regional lateralization of language representation in individual unselected patients with epilepsy.

Item Type: Article
Authors :
NameEmailORCID
Fernández G., UNSPECIFIEDUNSPECIFIED
Specht K., UNSPECIFIEDUNSPECIFIED
Weis S., UNSPECIFIEDUNSPECIFIED
Tendolkar I., UNSPECIFIEDUNSPECIFIED
Reuber M., UNSPECIFIEDUNSPECIFIED
Fell J., UNSPECIFIEDUNSPECIFIED
Klaver P., UNSPECIFIEDUNSPECIFIED
Ruhlmann J., UNSPECIFIEDUNSPECIFIED
Reul J., UNSPECIFIEDUNSPECIFIED
Elger C.E., UNSPECIFIEDUNSPECIFIED
Date : 2003
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 10:41
Last Modified : 17 May 2017 10:41
URI: http://epubs.surrey.ac.uk/id/eprint/828792

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