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Can rituximab induce long-term disease remission in patients with intra-ocular non-infectious inflammation?

Tomkins-Netzer, O, Taylor, SRJ and Lightman, S (2013) Can rituximab induce long-term disease remission in patients with intra-ocular non-infectious inflammation? Ophthalmologica, 230 (3). pp. 109-115.

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Abstract

Treatment of non-infectious uveitis is based primarily on the use of systemic corticosteroids and second-line immunosuppressive drugs. However, their extensive side effect profile, particularly for steroids, has led to the increased use of other immunosuppressive drugs, as sparing capacity agents. Rituximab is an anti-CD20 chimeric antibody, often given as a single course of 2 infusions, resulting in complete depletion of peripheral mature B cells. While it is licensed to treat refractory systemic lymphoma patients, it has also shown promising results in systemic auto-immune diseases, where a single course of treatment is able to achieve long-term clinical remission. Treatment with rituximab has been reported for various ocular conditions, suggesting it may be effective in inducing long-term disease control and other systemic immunosuppressive agents can be reduced or discontinued. When disease relapse occurs, a further course or courses can be given with good results. This review summarizes the current evidence regarding the role of rituximab in treating non-infectious uveitis. © 2013 S. Karger AG, Basel.

Item Type: Article
Authors :
NameEmailORCID
Tomkins-Netzer, OUNSPECIFIEDUNSPECIFIED
Taylor, SRJs.r.taylor@surrey.ac.ukUNSPECIFIED
Lightman, SUNSPECIFIEDUNSPECIFIED
Date : 1 September 2013
Identification Number : https://doi.org/10.1159/000351426
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 10:41
Last Modified : 17 May 2017 14:51
URI: http://epubs.surrey.ac.uk/id/eprint/828783

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