A web-based intervention (RESTORE) to support self-management of cancer-related fatigue following primary cancer treatment: a multi-centre proof of concept randomised controlled trial

Foster, C, Grimmett, C, May, CM, Ewings, S, Myall, M, Hulme, C, Smith, PW, Powers, C, Calman, L, Armes, Jo et al, Breckons, M, Corner, J, Fenlon, D, Batehup, L, Lennan, E, May, CR, Morris, C, Neylon, A, Ream, E, Turner, L, Yardley, L and Richardson, A (2016) A web-based intervention (RESTORE) to support self-management of cancer-related fatigue following primary cancer treatment: a multi-centre proof of concept randomised controlled trial Supportive Care in Cancer, 24 (6). pp. 2445-2453.

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Abstract

Purpose Cancer-related fatigue (CRF) is a frequent and distressing symptom experienced after cancer treatment. RESTORE is the first web-based resource designed to enhance self-efficacy to manage CRF following curative-intent treatment. The aim of this study is to test the proof of concept and inform the design of an effectiveness trial.

Methods A multi-centre parallel-group two-armed (1:1) exploratory randomised controlled trial (RCT) with qualitative process evaluation was employed in the study. Participants (≥18 years; ≤5 years post treatment with moderate to severe fatigue) were recruited and randomly assigned to RESTORE or a leaflet. Feasibility and acceptability were measured by recruitment, attrition, intervention adherence, completion of outcome measures and process evaluation. Change in self-efficacy to manage CRF was also explored. Outcome measures were completed at baseline (T0), 6 weeks (T1) and 12 weeks (T2). Data were analysed using mixed-effects linear regression and directed content analysis.

Results One hundred and sixty-three people participated in the trial and 19 in the process evaluation. The intervention was feasible (39 % of eligible patients consented) and acceptable (attrition rate 36 %). There was evidence of higher fatigue self-efficacy at T1 in the intervention group vs comparator (mean difference 0.51 [−0.08 to 1.11]), though the difference in groups decreased by 12 weeks. Time since diagnosis influenced perceived usefulness of the intervention. Modifications were suggested.

Conclusion Proof of concept was achieved. The RESTORE intervention should be subject to a definitive trial with some adjustments. Provision of an effective supportive resource would empower cancer survivors to manage CRF after treatment completion.

Item Type:	Article
Divisions :	Faculty of Health and Medical Sciences > School of Health Sciences
Authors :	Name Email ORCID Foster, C Grimmett, C May, CM Ewings, S Myall, M Hulme, C Smith, PW Powers, C Calman, L Armes, Jo jo.armes@surrey.ac.uk Breckons, M Corner, J Fenlon, D Batehup, L Lennan, E May, CR Morris, C Neylon, A Ream, E e.ream@surrey.ac.uk Turner, L Yardley, L Richardson, A
Date :	1 June 2016
Identification Number :	10.1007/s00520-015-3044-7
Copyright Disclaimer :	This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http:// creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Uncontrolled Keywords :	Science & Technology, Life Sciences & Biomedicine, Oncology, Health Care Sciences & Services, Rehabilitation, Cancer, Fatigue, Web-based, Self-management, Intervention, EXPLORATORY TRIAL, SURVIVORS, DEPRESSION, EFFICACY, ANXIETY, EXPLANATION, SEVERITY, PROGRAM, SCALE
Depositing User :	Symplectic Elements
Date Deposited :	17 May 2017 10:40
Last Modified :	07 Dec 2017 08:32
URI:	http://epubs.surrey.ac.uk/id/eprint/828733

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