University of Surrey

Test tubes in the lab Research in the ATI Dance Research

Particulate matter air pollution components and risk for lung cancer.

Raaschou-Nielsen, O, Beelen, R, Wang, M, Hoek, G, Andersen, ZJ, Hoffmann, B, Stafoggia, M, Samoli, E, Weinmayr, G, Dimakopoulou, K, Nieuwenhuijsen, M, Xun, WW, Fischer, P, Eriksen, KT, Sørensen, M, Tjønneland, A, Ricceri, F, de Hoogh, K, Key, T, Eeftens, M, Peeters, PH, Bueno-de-Mesquita, HB, Meliefste, K, Oftedal, B, Schwarze, PE, Nafstad, P, Galassi, C, Migliore, E, Ranzi, A, Cesaroni, G, Badaloni, C, Forastiere, F, Penell, J, De Faire, U, Korek, M, Pedersen, N, Östenson, CG, Pershagen, G, Fratiglioni, L, Concin, H, Nagel, G, Jaensch, A, Ineichen, A, Naccarati, A, Katsoulis, M, Trichpoulou, A, Keuken, M, Jedynska, A, Kooter, IM, Kukkonen, J, Brunekreef, B, Sokhi, RS, Katsouyanni, K and Vineis, P (2016) Particulate matter air pollution components and risk for lung cancer. Environ Int, 87. pp. 66-73.

Full text not available from this repository.

Abstract

BACKGROUND: Particulate matter (PM) air pollution is a human lung carcinogen; however, the components responsible have not been identified. We assessed the associations between PM components and lung cancer incidence. METHODS: We used data from 14 cohort studies in eight European countries. We geocoded baseline addresses and assessed air pollution with land-use regression models for eight elements (Cu, Fe, K, Ni, S, Si, V and Zn) in size fractions of PM2.5 and PM10. We used Cox regression models with adjustment for potential confounders for cohort-specific analyses and random effect models for meta-analysis. RESULTS: The 245,782 cohort members contributed 3,229,220 person-years at risk. During follow-up (mean, 13.1 years), 1878 incident cases of lung cancer were diagnosed. In the meta-analyses, elevated hazard ratios (HRs) for lung cancer were associated with all elements except V; none was statistically significant. In analyses restricted to participants who did not change residence during follow-up, statistically significant associations were found for PM2.5 Cu (HR, 1.25; 95% CI, 1.01-1.53 per 5 ng/m(3)), PM10 Zn (1.28; 1.02-1.59 per 20 ng/m(3)), PM10 S (1.58; 1.03-2.44 per 200 ng/m(3)), PM10 Ni (1.59; 1.12-2.26 per 2 ng/m(3)) and PM10 K (1.17; 1.02-1.33 per 100 ng/m(3)). In two-pollutant models, associations between PM10 and PM2.5 and lung cancer were largely explained by PM2.5 S. CONCLUSIONS: This study indicates that the association between PM in air pollution and lung cancer can be attributed to various PM components and sources. PM containing S and Ni might be particularly important.

Item Type: Article
Authors :
NameEmailORCID
Raaschou-Nielsen, OUNSPECIFIEDUNSPECIFIED
Beelen, RUNSPECIFIEDUNSPECIFIED
Wang, MUNSPECIFIEDUNSPECIFIED
Hoek, GUNSPECIFIEDUNSPECIFIED
Andersen, ZJUNSPECIFIEDUNSPECIFIED
Hoffmann, BUNSPECIFIEDUNSPECIFIED
Stafoggia, MUNSPECIFIEDUNSPECIFIED
Samoli, EUNSPECIFIEDUNSPECIFIED
Weinmayr, GUNSPECIFIEDUNSPECIFIED
Dimakopoulou, KUNSPECIFIEDUNSPECIFIED
Nieuwenhuijsen, MUNSPECIFIEDUNSPECIFIED
Xun, WWUNSPECIFIEDUNSPECIFIED
Fischer, PUNSPECIFIEDUNSPECIFIED
Eriksen, KTUNSPECIFIEDUNSPECIFIED
Sørensen, MUNSPECIFIEDUNSPECIFIED
Tjønneland, AUNSPECIFIEDUNSPECIFIED
Ricceri, FUNSPECIFIEDUNSPECIFIED
de Hoogh, KUNSPECIFIEDUNSPECIFIED
Key, TUNSPECIFIEDUNSPECIFIED
Eeftens, MUNSPECIFIEDUNSPECIFIED
Peeters, PHUNSPECIFIEDUNSPECIFIED
Bueno-de-Mesquita, HBUNSPECIFIEDUNSPECIFIED
Meliefste, KUNSPECIFIEDUNSPECIFIED
Oftedal, BUNSPECIFIEDUNSPECIFIED
Schwarze, PEUNSPECIFIEDUNSPECIFIED
Nafstad, PUNSPECIFIEDUNSPECIFIED
Galassi, CUNSPECIFIEDUNSPECIFIED
Migliore, EUNSPECIFIEDUNSPECIFIED
Ranzi, AUNSPECIFIEDUNSPECIFIED
Cesaroni, GUNSPECIFIEDUNSPECIFIED
Badaloni, CUNSPECIFIEDUNSPECIFIED
Forastiere, FUNSPECIFIEDUNSPECIFIED
Penell, Jj.penell@surrey.ac.ukUNSPECIFIED
De Faire, UUNSPECIFIEDUNSPECIFIED
Korek, MUNSPECIFIEDUNSPECIFIED
Pedersen, NUNSPECIFIEDUNSPECIFIED
Östenson, CGUNSPECIFIEDUNSPECIFIED
Pershagen, GUNSPECIFIEDUNSPECIFIED
Fratiglioni, LUNSPECIFIEDUNSPECIFIED
Concin, HUNSPECIFIEDUNSPECIFIED
Nagel, GUNSPECIFIEDUNSPECIFIED
Jaensch, AUNSPECIFIEDUNSPECIFIED
Ineichen, AUNSPECIFIEDUNSPECIFIED
Naccarati, AUNSPECIFIEDUNSPECIFIED
Katsoulis, MUNSPECIFIEDUNSPECIFIED
Trichpoulou, AUNSPECIFIEDUNSPECIFIED
Keuken, MUNSPECIFIEDUNSPECIFIED
Jedynska, AUNSPECIFIEDUNSPECIFIED
Kooter, IMUNSPECIFIEDUNSPECIFIED
Kukkonen, JUNSPECIFIEDUNSPECIFIED
Brunekreef, BUNSPECIFIEDUNSPECIFIED
Sokhi, RSUNSPECIFIEDUNSPECIFIED
Katsouyanni, KUNSPECIFIEDUNSPECIFIED
Vineis, PUNSPECIFIEDUNSPECIFIED
Date : February 2016
Identification Number : https://doi.org/10.1016/j.envint.2015.11.007
Uncontrolled Keywords : Air pollution, Cohort study, Lung cancer, Nickel, Particulate matter, Sulfur
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 10:40
Last Modified : 17 May 2017 10:40
URI: http://epubs.surrey.ac.uk/id/eprint/828731

Actions (login required)

View Item View Item

Downloads

Downloads per month over past year


Information about this web site

© The University of Surrey, Guildford, Surrey, GU2 7XH, United Kingdom.
+44 (0)1483 300800