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Changes in Membrane Receptors and Ion Channels as Potential Biomarkers for Osteoarthritis.

Lewis, R and Barrett-Jolley, R (2015) Changes in Membrane Receptors and Ion Channels as Potential Biomarkers for Osteoarthritis. Front Physiol, 6.

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Abstract

Osteoarthritis (OA), a degenerative joint condition, is currently difficult to detect early enough for any of the current treatment options to be completely successful. Early diagnosis of this disease could increase the numbers of patients who are able to slow its progression. There are now several diseases where membrane protein biomarkers are used for early diagnosis. The numbers of proteins in the membrane is vast and so it is a rich source of potential biomarkers for OA but we need more knowledge of these before they can be considered practical biomarkers. How are they best measured and are they selective to OA or even certain types of OA? The first step in this process is to identify membrane proteins that change in OA. Here, we summarize several ion channels and receptors that change in OA models and/or OA patients, and may thus be considered candidates as novel membrane biomarkers of OA.

Item Type: Article
Authors :
NameEmailORCID
Lewis, Rrebecca.lewis@surrey.ac.ukUNSPECIFIED
Barrett-Jolley, RUNSPECIFIEDUNSPECIFIED
Date : 2015
Identification Number : https://doi.org/10.3389/fphys.2015.00357
Uncontrolled Keywords : biomarkers, cartilage, chondrocytes, ion channels, osteoarthritis
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 10:40
Last Modified : 17 May 2017 14:51
URI: http://epubs.surrey.ac.uk/id/eprint/828728

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