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Age dependent electroencephalographic changes in attention-deficit/hyperactivity disorder (ADHD).

Poil, SS, Bollmann, S, Ghisleni, C, O'Gorman, RL, Klaver, P, Ball, J, Eich-Höchli, D, Brandeis, D and Michels, L (2014) Age dependent electroencephalographic changes in attention-deficit/hyperactivity disorder (ADHD). Clin Neurophysiol, 125 (8). pp. 1626-1638.

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Abstract

OBJECTIVE: Objective biomarkers for attention-deficit/hyperactivity disorder (ADHD) could improve diagnostics or treatment monitoring of this psychiatric disorder. The resting electroencephalogram (EEG) provides non-invasive spectral markers of brain function and development. Their accuracy as ADHD markers is increasingly questioned but may improve with pattern classification. METHODS: This study provides an integrated analysis of ADHD and developmental effects in children and adults using regression analysis and support vector machine classification of spectral resting (eyes-closed) EEG biomarkers in order to clarify their diagnostic value. RESULTS: ADHD effects on EEG strongly depend on age and frequency. We observed typical non-linear developmental decreases in delta and theta power for both ADHD and control groups. However, for ADHD adults we found a slowing in alpha frequency combined with a higher power in alpha-1 (8-10Hz) and beta (13-30Hz). Support vector machine classification of ADHD adults versus controls yielded a notable cross validated sensitivity of 67% and specificity of 83% using power and central frequency from all frequency bands. ADHD children were not classified convincingly with these markers. CONCLUSIONS: Resting state electrophysiology is altered in ADHD, and these electrophysiological impairments persist into adulthood. SIGNIFICANCE: Spectral biomarkers may have both diagnostic and prognostic value.

Item Type: Article
Authors :
NameEmailORCID
Poil, SSUNSPECIFIEDUNSPECIFIED
Bollmann, SUNSPECIFIEDUNSPECIFIED
Ghisleni, CUNSPECIFIEDUNSPECIFIED
O'Gorman, RLUNSPECIFIEDUNSPECIFIED
Klaver, Pp.klaver@surrey.ac.ukUNSPECIFIED
Ball, JUNSPECIFIEDUNSPECIFIED
Eich-Höchli, DUNSPECIFIEDUNSPECIFIED
Brandeis, DUNSPECIFIEDUNSPECIFIED
Michels, LUNSPECIFIEDUNSPECIFIED
Date : August 2014
Identification Number : 10.1016/j.clinph.2013.12.118
Uncontrolled Keywords : Attention-deficit/hyperactivity disorder, Development, Electroencephalography, Eyes-closed resting-state, Linear regression, Support vector machine, Adolescent, Adult, Aged, Aging, Attention, Attention Deficit Disorder with Hyperactivity, Child, Electroencephalography, Female, Humans, Male, Middle Aged, Prognosis, Regression Analysis, Rest, Sensitivity and Specificity, Support Vector Machine, Young Adult
Related URLs :
Depositing User : Symplectic Elements
Date Deposited : 17 May 2017 10:39
Last Modified : 17 May 2017 14:51
URI: http://epubs.surrey.ac.uk/id/eprint/828696

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